CD BioGlyco has developed specialized analytical solutions for Pharmaceutical Excipients to help clients characterize the performance of pharmaceutical excipients through various physical and chemical means. In addition, our Pharmaceutical and Biological Analysis Service also includes Pharmaceutical Analysis Service and Biological Evaluation Service.
We use a variety of methods to study the functional indicators of vacant hydroxypropyl starch capsules to help you evaluate and optimize pharmaceutical formulations. Our vacant hydroxypropyl starch capsule analysis services are as follows:
We use chemical methods to identify whether the sample contains hydroxypropyl starch. There are two commonly used methods: 1) Add iodine to observe whether the solution appears blue or reddish-purple; 2) Use the ninhydrin method to test.
Gently pinch both ends of the capsule with your thumb and forefinger, rotate, and pull it out without any sticking, deformation, or cracking. Then fill it with talc, cover and lock the cap and body, and drop the capsules one by one from a height of 1 m into a layer with a thickness of 2 cm on the board.
Put the sample into a desiccator containing a saturated solution of magnesium nitrate, keep it at 25°C for 24 h, then immediately put it into a glass tube, drop the weight freely from the mouth of the glass tube, and observe whether the capsule is broken.
Use a lifting disintegration instrument to check whether the hydroxypropyl starch capsules can be completely disintegrated within the specified time.
Take the sample and dry it at 130°C for 90 min. Calculate the drying weight loss of the test sample based on the weight loss and the sampling amount.
Take the sample and place it in a crucible that has been heated to constant weight, slowly burn it until it is completely carbonized, add sulfuric acid and heat it at low temperature until the sulfuric acid vapor is removed, and then check the amount of transparent residue, translucent residue, and opaque residue respectively.
The remaining residue from the ignition residue is taken and reacted with thioacetamide under specific conditions to determine the content of metal impurities in the sample.
Use prescribed methods to test the microbial content in vacant hydroxypropyl starch capsule samples, such as mold, yeast, and Escherichia coli.
Technology: Modified starch and pharmaceutical excipient
Journal: Polymers
IF: 5.0
Published: 2022
Results: The authors modified starch extracted from rice to obtain pregelatinized starch, carboxymethyl starch, cross-linked carboxymethyl starch, cross-linked starch, and hydroxypropyl starch. Then their physicochemical properties and functional properties were evaluated by some means. The results showed that compared with natural starch, the modified starch showed better hygroscopicity, swelling, powder flowability, and compressibility, and could be developed as a new pharmaceutical excipient.
Fig.1 X-ray diffraction (XRD) profiles of native and modified starches. (Kittipongpatana & Kittipongpatana, 2022)
Hard capsules refer to capsules that use appropriate preparation technology to fill hollow capsules with raw materials or uniform powders, granules, small tablets, pellets, semi-solids, or liquids made with appropriate excipients.
Vacant hydroxypropyl starch capsules are different from traditional gelatin hollow capsules. They are plant hard capsules made of pure natural pregelatinized starch and other excipients. Its raw materials come from a wide range of sources and are low in price. It retains all the advantages of standard vacant capsules and has technical advantages and characteristics that traditional gelatin vacant capsules do not have.
CD BioGlyco uses trusted technology to help clients evaluate and analyze the quality and reliability of hydroxypropyl starch capsules. Please feel free to contact us for more details about hydroxypropyl starch capsules analysis.
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