Properties
Description
AMG706, soluble in DMSO and ethanol and insoluble in water, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against VEGFR. It targets VEGFR1, VEGFR2, and VEGFR3.
Molecular Formula
C22H23N5O
Targets
VEGFR1: 2 nM; VEGFR2: 3 nM; VEGFR3: 6 nM
Solubility
DMSO: 68 mg/mL (182.09 mM); Water: Insoluble; Ethanol: 7 mg/mL (18.74 mM)
Identity
Confirmed by NMR/HPLC/MS.
Applications
AMG706 serves dual roles as both PDGFR and VEGFR inhibitor, relevant in studies targeting angiogenesis and stromal support in cancers.
