VEGFR inhibitor Axitinib, Purity ≥98%

Synonym: 319460-85-0; VEGFR inhibitor; AG 013736

MDL: MFCD09837898
CAS Number: 319460-85-0
Compound CID: 6450551

Product Size

50 mg; 100 mg; 250 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Axitinib, soluble in warmed DMSO and insoluble in water and ethanol, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against VEGFR. It targets VEGFR2/Flk1, VEGFR2/KDR, CSF-1R, FLT3, Kit, PDGFRα, PDGFRβ, VEGFR1/FLT1, and VEGFR3.

Molecular Weight

386.5

Molecular Formula

C₂₂H₁₈N₄OS

Targets

VEGFR2/Flk1: 0.18 nM; VEGFR2/KDR: 0.2 nM; CSF-1R: 73 nM; FLT3: >1 μM; Kit: 1.7 nM; PDGFRα: 5 nM; PDGFRβ: 1.6 nM; VEGFR1/FLT1: 0.1 nM; VEGFR3: 0.1-0.3 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 30 mg/mL (77.62 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

Axitinib acts on VEGFR, relevant in cancer research for its role in blocking blood supply to tumors.