VEGFR inhibitor AZD2171, Purity ≥98%

Synonym: 288383-20-0; VEGFR inhibitor; Recentin

MDL: MFCD09954115
CAS Number: 288383-20-0
Compound CID: 9933475

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

AZD2171, soluble in DMSO and insoluble in ethanol and water, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against VEGFR. It targets c-Kit, VEGFR3/FLT4, Abl, Aurora A, AuroraB, CDK2, CDK4, CSF-1R, EGFR, and FGFR1.

Molecular Weight

450.5

Molecular Formula

C₂₅H₂₇FN₄O₃

Targets

c-Kit: 2 nM; VEGFR3/FLT4: ≤3 nM; Abl: 260 nM; AuroraA: >10 μM; AuroraB: >10 μM; CDK2: >1 μM; CDK4: >1 μM; CSF-1R: 110 nM; EGFR: 1.6 nM; FGFR1: 26 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 80 mg/mL (177.57 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

AZD2171 inhibits VEGFR, supporting its use in researching anti-angiogenic strategies in oncology.