VEGFR inhibitor CYC116, Purity ≥98%

Synonym: 693228-63-6; CYC-116; CYC116; 4-Methyl-5-(2-(4-morpholinophenylamino)pyrimidin-4-yl)thiazol-2-amine; CYC 116; VEGFR inhibitor

MDL: MFCD14155805
CAS Number: 693228-63-6
Compound CID: 6420138

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

CYC116, soluble in warmed DMSO and insoluble in water and ethanol, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against VEGFR. It targets Aurora B, VEGFR2, Abl, Akt, AuroraA, CaMKII, CDK1/CyclinB, CDK1/CyclinB, CDK1/CyclinB, CDK7/CyclinH, and CDK9/CyclinT.

Molecular Weight

368.5

Molecular Formula

C₁₈H₂₀N₆OS

Targets

Aurora B: 9 nM (Ki); VEGFR2: 44 nM (Ki); Abl: >10 μM (Ki); Akt: >10 μM (Ki); AuroraA: 8 nM (Ki); CaMKII: >10 μM (Ki); CDK1/CyclinB: >10 μM (Ki); CDK1/CyclinB: 0.39 μM (Ki); CDK1/CyclinB: 1.09 μM (Ki); CDK7/CyclinH: >10 μM (Ki); CDK9/CyclinT: 0.48 μM (Ki)

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 24 mg/mL (65.13 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

CYC116 is used to study the effects of dual Aurora kinase and VEGFR2 inhibition in oncology research.

Storage

Store at -20ºC.