VEGFR inhibitor CYC116, Purity ≥98%

Synonym: 693228-63-6; CYC-116; CYC116; 4-Methyl-5-(2-(4-morpholinophenylamino)pyrimidin-4-yl)thiazol-2-amine; CYC 116; VEGFR inhibitor

MDL: MFCD14155805
CAS Number: 693228-63-6
Compound CID: 6420138

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

CYC116, soluble in warmed DMSO and insoluble in water and ethanol, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against VEGFR. It targets Aurora B, VEGFR2, Abl, Akt, AuroraA, CaMKII, CDK1/CyclinB, CDK1/CyclinB, CDK1/CyclinB, CDK7/CyclinH, and CDK9/CyclinT.

Molecular Weight

368.5

Molecular Formula

C₁₈H₂₀N₆OS

Targets

Aurora B: 9 nM (Ki); VEGFR2: 44 nM (Ki); Abl: >10 μM (Ki); Akt: >10 μM (Ki); AuroraA: 8 nM (Ki); CaMKII: >10 μM (Ki); CDK1/CyclinB: >10 μM (Ki); CDK1/CyclinB: 0.39 μM (Ki); CDK1/CyclinB: 1.09 μM (Ki); CDK7/CyclinH: >10 μM (Ki); CDK9/CyclinT: 0.48 μM (Ki)

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 24 mg/mL (65.13 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

CYC116 is used to study the effects of dual Aurora kinase and VEGFR2 inhibition in oncology research.