VEGFR inhibitor ENMD-2076, Purity ≥98%

Synonym: ENMD-2076; 934353-76-1; ENMD 2076; (E)-N-(5-Methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-2-styrylpyrimidin-4-amine; ENMD2076; VEGFR inhibitor

MDL: MFCD18074523
CAS Number: 934353-76-1, 1291074-87-7
Compound CID: 16041424

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

ENMD-2076, soluble in DMSO and water and insoluble in ethanol, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against VEGFR. It targets Aurora A, RET, Abl1 (T315I), Aurora B, BLK, CSF-1R/c-Fms, FAK, FGFR1, FGFR2, FLT3, and Fyn.

Molecular Weight

375.5

Molecular Formula

C₂₁H₂₅N₇

Targets

Aurora A: 14 nM; RET: 10.4 nM; Abl1 (T315I): 81.3 nM; Aurora B: 350 nM; BLK: 69.4 nM; CSF-1R/c-Fms: 24.8 nM; FAK: 54.9 nM; FGFR1: 92.7 nM; FGFR2: 70.8 nM; FLT3: 1.86 nM; Fyn: 112 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 101 mg/mL (268.99 mM); Water: 1 mg/mL (2.66 mM); Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

ENMD-2076 can be used to investigate the inhibition of Aurora kinase A and angiogenesis in cancer studies.