VEGFR inhibitor GSK1363089, Purity ≥98%

Synonym: 849217-64-7; VEGFR inhibitor; GSK089; EXEL-2880

MDL: MFCD16038048
CAS Number: 849217-64-7
Compound CID: 42642645

Product Size

5 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

GSK1363089, soluble in DMSO and insoluble in ethanol and water, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against VEGFR. It targets KDR, Tie-2, EGFR, FGFR1, FLT3, Kit, Met, PDGFRα, PDGFRβ, RON, and VEGFR1/FLT1.

Molecular Weight

632.7

Molecular Formula

C₃₄H₃₄F₂N₄O₆

Targets

KDR: 0.86 nM; Tie-2: 1.1 nM; EGFR: 2.99 nM; FGFR1: 660 nM; FLT3: 3.6 nM; Kit: 6.7 nM; Met: 0.4 nM; PDGFRα: 3.6 nM; PDGFRβ: 9.6 nM; RON: 3 nM; VEGFR1/FLT1: 6.8 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 87 mg/mL (137.51 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

GSK1363089 is a VEGFR inhibitor, aiding in research on inhibiting angiogenic signaling pathways in cancers.