VEGFR inhibitor OSI-930, Purity ≥98%

Synonym: 728033-96-3; VEGFR inhibitor; OSI930

CAS Number: 728033-96-3
Compound CID: 9868037

Product Size

5 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

OSI-930, soluble in DMSO and ethanol and insoluble in water, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against VEGFR. It targets CSF-1R, KDR, Abl, Aurora A, Axl, C-Raf, CDK2/CyclinA, EGFR, FLT1, FLT3, and IKKβ.

Molecular Weight

443.4

Molecular Formula

C₂₂H₁₆F₃N₃O₂S

Targets

CSF-1R: 15 nM; KDR: 9 nM; Abl: 4.738 μM; AuroraA: >10 μM; Axl: >10 μM; C-Raf: 41 nM; CDK2/CyclinA: >10 μM; EGFR: >10 μM; FLT1: 8 nM; FLT3: 1.303 μM; IKKβ: >10 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 85 mg/mL (191.68 mM); Water: Insoluble; Ethanol: 3 mg/mL

Identity

Confirmed by NMR/HPLC/MS.

Applications

VEGFR inhibitor OSI-930 is employed to understand the inhibition of VEGFRs, important for developing anti-cancer strategies targeting tumor blood supply.