VEGFR inhibitor XL184 free base, Purity ≥98%

Synonym: 849217-68-1; VEGFR inhibitor; BMS-907351

MDL: MFCD20926324
CAS Number: 849217-68-1
Compound CID: 25102847

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

XL184 free base, soluble in DMSO and insoluble in ethanol and water, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against VEGFR. It targets Flt-1, Flt-4, and VEGFR2.

Molecular Weight

501.5

Molecular Formula

C₂₈H₂₄FN₃O₅

Targets

Flt-1: 12 nM; Flt-4: 6 nM; VEGFR2: 0.035 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 92 mg/mL (183.44 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

XL184 free base inhibits VEGFR and is used to explore anti-angiogenic therapy in oncology.