Properties
Description
Vortioxetine (Lu AA21004) hydrobromide, soluble in DMSO and ethanol and insoluble in water, inhibits the signaling pathway between G-protein-coupled receptors (GPCRs) and G proteins. It targets 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7, and SERT.
Molecular Formula
C18H22N2S·HBr
Targets
5-HT1A: 15 nM (Ki); 5-HT1B: 33 nM (Ki); 5-HT3A: 3.7 nM (Ki); 5-HT7: 19 nM (Ki); SERT: 1.6 nM (Ki)
Solubility
DMSO: 68 mg/mL (179.24 mM); Water: insoluble; Ethanol: 15 mg/mL (39.54 mM)
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
Vortioxetine hydrobromide can be studied for its effect on enhancing the activity of serotonin in the brain, which is involved in regulating mood.
Storage
Store at -20°C, and keep desiccated.
