Properties
Description
VU 0364770, soluble in DMSO and ethanol and insoluble in water, inhibits the signaling pathway between G-protein-coupled receptors (GPCRs) and G proteins. It targets human mGlu4, mGlu5, mGlu6, and rat mGlu4.
Molecular Formula
C12H9ClN2O
Targets
Human mGlu4: 1.1 μM (EC50); mGlu5: 17.9 μM (EC50); mGlu6: 6.8 μM (EC50); Rat mGlu4: 290 nM (EC50)
Solubility
DMSO: 46 mg/mL (197.7 mM); Water: insoluble; Ethanol: 46 mg/mL (197.7 mM)
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
VU 0364770 can be used for its ability to enhance the activity of the mGluR5 receptor, which may lead to improved cognitive function and behavioral outcomes.
Storage
Store at -20°C, and keep desiccated.
