Properties
Description
Ziprasidone hydrochloride monohydrate, soluble in DMSO and insoluble in water and ethanol, inhibits the signaling pathway between G-protein-coupled receptors (GPCRs) and G proteins. It targets rat 5-HT1A receptor, rat 5-HT2A, and rat D2 receptor.
Molecular Formula
C21H24Cl2N4O2S
Targets
Rat 5-HT1A receptor: 3.4 nM; Rat 5-HT2A: 0.42 nM; Rat D2 receptor: 4.8 nM
Solubility
DMSO: 86 mg/mL (191.36 mM); Water: insoluble; Ethanol: insoluble
Applications
Ziprasidone hydrochloride monohydrate can be used to help alleviate psychotic symptoms such as hallucinations, delusions, disorganized thinking, and emotional withdrawal associated with schizophrenia.