Properties
Description
Afuresertib, soluble in DMSO and ethanol and insoluble in water, inhibits the phosphorylation of Akt with anti-inflammatory properties. It targets Akt1 E17K mutant, Akt2, Akt3, PKCη, PKCθ, PKC-βI, and ROCK.
Molecular Formula
C18H17Cl2FN4OS
Targets
Akt1 E17K mutant: 0.2 nM; Akt2: 2 nM (Ki); Akt3: 2.6 nM (Ki); PKCη: 210 nM (Ki); PKCθ: 510 nM; PKC-βI: 430 nM; ROCK: 100 nM
Solubility
DMSO: 79 mg/mL (184.87 mM); Water: Insoluble; Ethanol: 79 mg/mL (184.87 mM)
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
Afuresertib can be used to study its inhibitory effect on Akt in cancer research.
