Akt inhibitor Afuresertib, Purity ≥98%

Synonym: 1047644-62-1; GSK 2110183; GSK2110183; GSK-2110183; Akt inhibitor

CAS Number: 1047644-62-1
Compound CID: 46843057

Product Size

5 mg; 10 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Afuresertib, soluble in DMSO and ethanol and insoluble in water, inhibits the phosphorylation of Akt with anti-inflammatory properties. It targets Akt1 E17K mutant, Akt2, Akt3, PKCη, PKCθ, PKC-βI, and ROCK.

Molecular Weight

427.32

Molecular Formula

C₁₈H₁₇Cl₂FN₄OS

Targets

Akt1 E17K mutant: 0.2 nM; Akt2: 2 nM (Ki); Akt3: 2.6 nM (Ki); PKCη: 210 nM (Ki); PKCθ: 510 nM; PKC-βI: 430 nM; ROCK: 100 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 79 mg/mL (184.87 mM); Water: Insoluble; Ethanol: 79 mg/mL (184.87 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

Afuresertib can be used to study its inhibitory effect on Akt in cancer research.