Glyconanotechnology-based Biosensor Development Service

Overview

At the intersection of biotechnology and nanoscience, glyconanomaterials are leading the new development of biosensing with their unique biocompatibility, recognition properties, and functional tunability. Based on the advanced GlycoNano™ Platform, CD BioGlyco focuses on the development of glycan-based nano biosensors and is committed to combining nature's glycan-based recognition mechanisms with advanced nanotechnology to provide clients with highly sensitive and selective biosensors.

Develop Sensors with Different Characteristics With us

Our nano biosensors are known for their high sensitivity, high specificity, and excellent stability, providing clients with reliable detection results. In the fields of biomedical diagnostics and environmental monitoring, the ability to accurately detect glucose, pathogenic bacteria, toxins, lectins, and biomarkers is critical. Our company is focused on developing a range of innovative biosensors utilizing glyconanotechnology to meet these needs.

Glucose Sensor Development

Our company provides glucose nano biosensor design and synthesis services based on the specific research needs of clients in different fields. Our areas of expertise cover enzymatic glucose biosensors, non-enzymatic glucose biosensors, quantum dot (QD) biosensors, and carbon dot biosensor development.

Pathogenic Bacteria and Toxin Sensor Development

We offer pathogenic bacteria and toxin sensor development services involving design, synthesis, testing, and optimization aimed at creating pathogenic bacteria-sugar recognition interfaces that mimic physiological environments and evaluating the anti-adhesion effects of different carbohydrates to optimize sensor performance.

Cytosensor Development

Combining cell culture technology with carbohydrate nanosensing elements, we offer cytosensor development services. These sensors use living cells as the core of detection and monitor and record cell behavior and state changes in real time, providing important information for biomedical research and applications.

Lectin Sensor Development

Relying on nano-biosensing technology, our company focuses on the immobilization of biomolecules at the sensing interface and the efficient conversion of biorecognition signals, aiming to provide lectin sensors with high sensitivity, selectivity, and stability to meet the needs of accurate detection.

Sensor Synthesis

Our company provides professional nanomaterial synthesis and structure-specific carbohydrate synthesis services. Moreover, our researchers select suitable nanomaterials, such as gold nanoparticles, QDs, carbon nanotubes, or magnetic nanoparticles, according to the application requirements of the sensors.

Modification

Surface functionalization: Our researchers chemically or physically introduce functional groups, such as carboxyl groups and amino groups, on the surface of nanomaterials to facilitate subsequent immobilization of active molecules.
Biomolecule conjugation: We offer immobilization of a wide range of biomolecules to enhance sensor recognition.

Schematic of constituents of biosensors and steps involved in the measurement process. (CD BioGlyco)

Characterization

Our company provides conformal and dimensional analysis, chemical composition analysis, surface functional group analysis, and functional evaluation services.
Our common analytical tools include but are not limited to, transmission electron microscopy (TEM), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), and X-ray photoelectron spectroscopy (XPS).

Workflow

Schematic of biosensor development. (CD BioGlyco)

Applications

Glyconanotechnology-based biosensors can be used to detect pathogenic bacteria and toxins such as Salmonella, E. coli, or botulinum toxin.
Glyconanotechnology-based biosensors can be used for drug screening and efficacy assessment, especially in the development of anticancer drugs and antibiotics. Moreover, it can also be used to monitor the distribution and metabolism of drugs in the body.
Glyconanotechnology-based biosensors can be used to study changes in cell surface glycoconjugates and understand their role in cell recognition and signaling.
Glyconanotechnology-based biosensors can be used to develop nanocarriers for targeted drug delivery to improve therapeutic efficacy and reduce side effects.

Advantages of Us

Our nano-biosensors have the advantages of specific sensitivity, simplicity and speed, real-time detection, low material consumption, and low detection limit.
Our highly trained development team consists of interdisciplinary experts covering a wide range of fields, including materials science, biotechnology, and electronic information.
Our company provides customized nanosensor solutions covering the entire process from conceptual design, precise synthesis, and functional modification to exhaustive characterization. Through this one-stop service, we ensure that the sensors demonstrate excellent performance and reliability while meeting specific assay needs.

Publication Data

Technology: Field emission scanning electron microscopes (FE-SEM), Energy dispersive X-ray spectrum (EDS), FT-IR

Journal: Biosensors

Published: 2022

IF: 4.9

Results: In this study, researchers prepared graphene oxide (GO)/Co/chitosan-based nano-biosensor using a combination of GO, cobalt chloride hexahydrate, chitosan, and gold film electrodes. Moreover, researchers used FE-SEM, EDS, and FT-IR to analyze and characterize the synthesized nano-biosensor was analyzed and characterized. The results showed that the cobalt nanorods formed in GO/Co/chitosan composites significantly facilitated electron transfer. It detected concentrations ranging from 1.0 to 15.0 mM. The nano biosensor showed excellent performance in real-time detection of D-glucose and is a candidate for miniaturized glucose biosensors.

Fig.1 Surface analysis using FE-SEM and elemental mapping images of the biosensor. Fig.1 Surface analysis and elemental mapping images. (Kim, et al., 2022)

Frequently Asked Questions

Are your company's sensors available for all types of samples?
Our sensors are highly flexible and adaptable, but specific sample suitability is determined by the sensor design and test results. We offer professional and customized solutions for different sample types and applications.
How to prepare polymetallic catalyst systems?
Preparation methods commonly used in our company include magnetron sputtering, chemical vapor deposition, pulsed laser, colloidal deposition, melting, and electrochemical methods.

CD BioGlyco provides development services for highly functional and specific nanosensors to further expand their applications. We are committed to being your best partner in nano-sensor development. No matter what type of biosensor you are interested in, please feel free to contact us to customize it for you!

Reference

Kim, D.S.; et al. Development of GO/Co/chitosan-based nano-biosensor for real-time detection of D-glucose. Biosensors. 2022; 12(7):464.

This service is for Research Use Only, not intended for any clinical use.