Glyconanotechnology-based Glucose Sensor Development Service

Glyconanotechnology-based Glucose Sensor Development Service

Overview

In the field of biomedical research and clinical diagnostics, accurate monitoring of glucose levels is critical for diabetes management, cancer research, and the diagnosis of many other metabolic diseases. Based on the high-quality GlycoNano™ Platform, CD BioGlyco aims to provide clients with a full range of support from basic research to preclinical applications, including customized glucose nano biosensor design, development, and validation services. If you want to customize other types of Glyconanotechnology-based Biosensors, our highly trained research team provides you with satisfactory development solutions.

Designing Your Glucose Sensor Based on Glyconanotechnology

Glucose Sensor Design and Synthesis

  • CD BioGlyco has experienced researchers to provide specific glucose nano biosensor design and synthesis services according to clients' research needs in different fields. Such as enzymatic glucose biosensors, non-enzymatic glucose biosensors, quantum dot (QD) biosensors, and carbon dots biosensors.
  • Our company provides synthesis services of nanomaterials such as QDs and carbon dots for the construction of high-performance biosensors. For example, Our lab uses physical adsorption and crosslinking liquid methods to modify nanostructured electrodes to prepare glucose sensors based on Au nanowire arrays and graphene.

Schematic diagram of different enzyme glucose sensors. (CD BioGlyco)

Glucose Sensor Modification

  • Our researchers provide specialized sensor modification services. We equip nanomaterials with glucose detection capabilities by conjugating specific recognition molecules such as enzymes, antibodies, or ligands.
  • The size and morphology of the nanoparticles affect their catalytic activity and detection performance, and their complexation with other nanomaterials leads to enhancement of their activity. In our company, we use a combination of electrochemical and magnetron sputtering methods to enhance the electrocatalytic performance by modulating the morphology of the nanoparticle distribution and compositing different metal nanoparticles such as Ni, Au, and Pd.

Glucose Sensor Performance Testing

  • We provide testing services for key performance indicators such as sensitivity, linear range, detection limit, stability, selectivity, and response time of the sensors to ensure that they meet the accuracy and reliability requirements in real-world applications.

Workflow

Schematic of glucose nanosensor development. (CD BioGlyco)

Applications

  • Glyconanotechnology-based glucose sensor helps clients to deeply analyze intracellular glucose and the relationship between intracellular glucose and the intracellular metabolic control system.
  • Glyconanotechnology-based glucose sensors can be used in biomedical research to explore the mechanisms of glucose metabolism.
  • Glyconanotechnology-based glucose sensor plays an important role in the diagnosis and mechanism study of blood glucose-related diseases.
  • Glyconanotechnology-based glucose sensors can be used in fermentation control, environmental protection, and food industry analysis.

Advantages of Us

  • High sensitivity and specificity: Our glyconanotechnology-based glucose sensors are based on advanced nanomaterials with extremely high sensitivity and specificity.
  • Our company has an advanced nano research platform to provide one-stop nanosensor development services from design synthesis to validation testing for clients all over the world to ensure the performance of the sensor meets the specific application scenarios.
  • Our company offers a wide range of nanosensors based on materials including but not limited to gold nanoparticles, carbon nanotubes, carbon/graphene QDs, and chitosan hydrogel composites.
  • For customized glucose sensors based on specific nanomaterials, our researchers provide you with high-quality synthesis solutions.

Publication Data

Technology: Fluorescence lifetime imaging microscopy (FLIM), Cell viability assay

Journal: Sensors

Published: 2019

IF: 3.4

Results: In this study, researchers developed a CdSe/ZnS QD and prepared QD-aminophenyl boronic acid (APBA) conjugates by modification with APBA as a glucose nanosensor. The results showed that the boronic acid groups on the surface of the quantum dots restored the photoluminescence (PL) intensity and enhanced the lifetime upon binding with glucose. The long PL lifetime of quantum dots enables them to be distinguished from cellular autofluorescence and improves sensing selectivity. This literature provides new tools for biomedical diagnostics and research utilizing quantum dots and FLIM technology.

Fig.1 Covalent coupling reaction scheme for the synthesis of QD-APBA.Fig.1 Covalent coupling synthesis route of QD-APBA. (Ripoll, et al., 2019)

Frequently Asked Questions

  • What are the common methods used to characterize glucose biosensors?
    Our company often uses X-ray diffraction analysis, scanning electron microscope (SEM) analysis, cyclic voltammetry, oxidation peak voltage studies, timed current response, and FLIM imaging to characterize glucose sensors. If you need a specific analytical report, we offer customized analysis routes for you to choose from.
  • What is the detection range of the glucose nano biosensor?
    The glyconanotechnology-based glucose sensors offered by our company can be adapted to the client's needs to cover the range of concentrations from micromolar to millimolar.
  • How to synthesize copper metal nanoparticles if you want to use them as part of a composite nanosensor?
    Our company uses chemical reduction, thermal decomposition of organic precursors, polyols, microemulsions, continuous electrodeposition, and pulsed electrochemical methods to prepare copper nanoparticles. According to clients' research needs in different fields, we provide corresponding synthesis and modification services.

CD BioGlyco provides high-quality glyconanotechnology-based glucose sensor development services to clients for various applications in biomedical research, the food industry, and environmental and biochemical fields. Feel free to contact us for the most suitable customized glucose sensor solution for you.

Reference

  1. Ripoll, C.; et al. A quantum dot-based FLIM glucose nanosensor. Sensors. 2019, 19(22): 4992.
This service is for Research Use Only, not intended for any clinical use.

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About Us

CD BioGlyco is a world-class biotechnology company with offices in many countries. Our products and services provide a viable option to what is otherwise available.

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