Biodegradable block polysaccharides are a relatively new class of biomacromolecules, based entirely on modules obtained directly from biomass. CD BioGlyco is committed to providing suitable block coupling methods for our customers' biodegradable block polysaccharide development needs. Our extensive experience in the field of chemical synthesis and our state-of-the-art technology provide multiple opportunities for the design and synthesis of novel block polysaccharide structures with new properties.
Abundant biomass is the basis for the large-scale industrial production of many polysaccharides. They are used in a wide range of applications, such as the development of food additives and pharmaceutical formulations. As a step towards a new generation of functional polysaccharides, scientists are increasingly interested in the development of engineering block polysaccharides, which consist of at least two polysaccharide blocks covalently linked by their chain ends. This involves the first excision of relevant blocks from parent polysaccharides by standard chemical or enzymatic methods, followed by reassembly at the end of the chain to form new and well-defined macromolecular structures.
Block polysaccharides offer many outstanding advantages over conventional, laterally substituted polysaccharide derivatives, including better retention of intrinsic chain properties such as stimulus-responsive self-assembly and biodegradability, as well as easy induction of new macromolecular properties. In addition to this, polysaccharide-based block copolymers have also received a lot of attention from scientists, as these polymers not only have the physicochemical properties of block copolymers, but in some cases have additional advantages such as biodegradability, biocompatibility, or bioactivity.
Fig.1 a) The principal types of engineered block polymers and b) comparison between polysaccharide derivatives and block polysaccharides. (Solberg, et al., 2021)
In addition to offering traditional methods based on Huisgen azide-alkyne cycloadditions, our researchers have focused on the latest applications of oxyamine and hydrazide 'click' reactions in the end-coupling of oligosaccharide and polysaccharide blocks to help clients synthesize novel biodegradable block polysaccharides. The use of dihydrazide (ADH) and dioxyamine molecules allows for rapid and quasi-quantitative coupling of polysaccharides through their chain ends. We typically use difunctional junctions like adipic acid ADH and O,O'-1,3-propanediyl-bishydroxylamine (PDHA) based on hydrazide and oxyamine groups, respectively, for the click chemistry of polysaccharides. Our efficient and simple solutions help clients to design and prepare a variety of block polysaccharide structures. Our services include but are not limited to:
With a first-class technology platform and an experienced research team, CD BioGlyco not only provides clients with the development services of conventional polysaccharide-based biomaterials but also provides solutions for the development of new Other Polysaccharide-based Biodegradable Materials, such as block polysaccharides. Our simple PDHA/ADH-based chemistry provides possibilities for the effective preparation of block polysaccharides.
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