Biodegradable Hyaluronate-Gold Development

Development of Hyaluronate-Gold Nanoparticles

The rapid development of NPs has important implications for tumor diagnosis, therapy, and monitoring because of their important contributions to detecting cancer cells, delivering chemotherapeutic agents, and controlling therapeutic responses. In recent years, several new-generation drug delivery vehicles, diagnostic systems, and contrast agents based on the use of NPs have been developed for theranostic applications. Among them, AuNPs have been widely used in various biomedical applications due to their biocompatibility, simple synthesis, convenient surface modification, and tunable optical properties.

Surface modifications with polymers and natural biomolecules are commonly used to improve the targeting and biocompatibility of AuNPs. HA has been widely used in the development of nanocarriers due to its excellent water solubility, biocompatibility, biodegradability, non-toxicity, and non-immunogenicity. HA was shown to perform effective "surface modification" on AuNPs, affecting the physicochemical properties of AuNPs. The modified nanocarriers exhibited preferential tumor accumulation and increased cellular uptake in cancer cells.

Fig.1 Schematic illustration of the synthesis of HA-capped AuNPs. (Sanfilippo, et al., 2020)

Biodegradable Hyaluronate-Gold Development Services at CD BioGlyco

Researchers at CD BioGlyco have been working for years on the development of Hyaluronic Acid-based Biodegradable Materials, including bioconjugated nanoparticles with enhanced biocompatibility. Considering the specific interaction of HA with the CD44 receptor, we help our clients develop HA-capped AuNPs for widespread use in active tumor targeting. Our services include but are not limited to:

• Synthesis of bare and HA-conjugated AuNP
  
  • We have established several green-like strategies to help clients obtain AuNPs under mild temperature conditions.
  • We help our clients synthesize HA-capped AuNPs through a green, reproducible one-step method based on a wet redox reaction at room temperature.
• Characterization of HA-AuNPs
  We offer a variety of technical methods including UV-visible spectroscopy, atomic force microscopy (AFM), and dynamic light scattering (DLS) to help clients characterize the physicochemical properties of HA-coated AuNPs, including hydrodynamic size, plasmonic peak characteristics, and the structure of core (metallic gold)-shell (glycoside) NPs.
• Antimicrobial activity and cytotoxicity analysis.
  We offer antimicrobial activity and cytotoxicity assays to help clients test the CD4-targeting ability of HA-coated AuNPs.
• Development and characterization of HA-AuNP hydrogel
  We provide clients with solutions to develop injectable HA-AuNP matrix with local stiffness that enhance gap junction formation in transplanted human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs) and promote cardiac repair.

CD BioGlyco provides clients with biodegradable hyaluronate-gold development and characterization services to expand the application of Polysaccharide-based Biodegradable Materials in the biomedical field.

If you are interested in our business, please feel free to contact us for more details, and we will respond promptly.