Oxidized regenerated cellulose (ORC) is widely sourced and highly biocompatible, making it a trusted wound hemostatic material for clinicians. CD BioGlyco is dedicated to assisting clients in the development of biodegradable ORCs, the optimization of manufacturing strategies, and the analysis of their hemostatic efficiency and biodegradability.
As a kind of cellulose derivative, ORC has the characteristics of good biocompatibility, biodegradability, and non-toxicity. ORC is a cellulose acid tulle-like or cotton-like absorbable hemostatic material that has been oxidized and processed. It has the appearance and texture of cotton yarn, is soft and thin, and is easy to wrap and stuff. ORC can also be manufactured in conjunction with collagen matrices. Typically, 55% bovine collagen is used in combination with 45% ORC for wound healing and repair.
ORC has been used as a surgical and dental hemostatic agent for nearly half a century and is effective in controlling venous, capillary, and arteriole bleeding in a variety of settings. In addition to this, aldehyde, carboxyl, or ketone groups present on ORC scaffolds can serve as sites for cell, protein/peptide, and drug attachment or further chemical modification to achieve induction of cell adhesion and subsequent proliferation. Therefore, ORCs have also received extensive attention from scientists as a potential biodegradable platform for tissue engineering and drug delivery.
Fig.1 Characterization of the materials: (A) FT-IR spectra of (a) ORC, (b) ORC-Na-1, (c) ORC-Na-2, (d) ORC-Na-3, (e) ORC-Na-4, and (B) molecular structures. (Wu, et al., 2012)
In the past ten years, CD BioGlyco has been committed to independent research and development around Cellulose-based Biodegradable Materials, including ORC, and providing professional scientific services to customers. We focus on the improvement of the preparation process to achieve rapid and uniform oxidation of regenerated cellulose. Our R&D team has screened and evaluated a variety of oxidation systems and overcome the technical barriers of reaction devices adapted to these oxidation systems to achieve stable product quality. The services we provide to our clients include but are not limited to:
Equipped with comprehensive physical and chemical instruments and rich experience in the development of Polysaccharide-based Biodegradable Materials, CD BioGlyco provides clients with professional solutions and technical support for ORC development and characterization projects.
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