Biomedical Applications of SA-Dex-OA

In the past few years, various nanomaterials including liposomes, nanoparticles, and micelles have been used to selectively deliver pharmaceutical agents to specific sites in the body and avoid secondary damage. Among them, polymer micelles have been widely considered by scientists as one of the potent nanocarriers. They are made of hydrophobic cores and hydrophilic shells. The inner core provides space and capacity to encapsulate hydrophobic drugs, while the outer shell stabilizes the micelles in blood circulation.

A new nanomaterial, SA-Dex-OA micelles, was recently developed for accurate drug delivery without invasive injury. Studies have reported the application of this material in targeted drug delivery systems for the treatment of rheumatoid arthritis (RA) and tumors. Xu et al. synthesized SA-Dex-OA micelles to encapsulate the antirheumatic drug methotrexate (MTX) and confirmed their potential as a drug delivery agent in the treatment of RA and other metabolic bone diseases with severe bone erosion through in vitro and in vivo studies. Zhu et al. designed a novel doxorubicin (DOX)-loaded SA-Dex-OA/DOX conjugate to improve tumor tissue accumulation and tumor cell transportation effectively.

Fig.1 Preparation and characterization of SA-Dex-OA micelles. (Xu, et al., 2018)

Biodegradable SA-Dex-OA Development Services at CD BioGlyco

The research team at CD BioGlyco is focused on the development of a variety of Dextran-based Biodegradable Materials, including degradable SA-Dex-OA, which is important in the development of targeted drug delivery systems. We provide clients with the synthesis and characterization services of SA-Dex-OA and SA-Dex-OA micelles, accelerating the development of drug delivery systems with strong specificity between carriers and receptors and minimal drug side effects. Our services include but are not limited to:

• Synthesis of SA-Dex-OA conjugates
  We usually help clients synthesize SA-Dex-OA in two steps:
  
  • Synthesis of Dex-OA conjugates via esterification between the carboxyl group of OA and the hydroxyl group of Dex.
  • Synthesis of SA-Dex-OA via acylation reaction.
• Characterization of SA-Dex-OA conjugates
  We provide various techniques such as nuclear magnetic resonance (¹H NMR) to verify the chemical structure of SA-Dex-OA polymers.
  
  • Preparation of blank and drug-loaded SA-Dex-OA micelles through solvent diffusion method
• Characterization of drug-loaded SA-Dex-OA micelles
  We provide professional technical support to help clients study the chemical structure, critical micelle concentration (CMC), size, morphology, drug-loading efficiency, and drug release kinetics of drug-loaded SA-Dex-OA micelles.

Our Advantages

• Cutting-edge technology and professional research team
• Rigorous experiment process
• Customize experimental programs according to research needs
• 24 hours after-sales service

As a world-leading Polysaccharide-based Biodegradable Materials supplier and manufacturer, CD BioGlyco provides professional solutions to help clients develop high-quality biodegradable SA-Dex-OA. Our top-notch scientific team is ready to produce custom products for you.

If you are interested in our business, please feel free to contact us for more details, and we will respond promptly.