CD BioGlyco, as a specialized company focusing on glycobiology research, we are committed to loading biologics into glyconanoparticles efficiently and precisely to break through the limitations of traditional drug delivery and open up new possibilities. Our Glyconanoparticle Formulation Services not only enhance the bioavailability and stability of the loaded materials, but also enables targeted delivery, reduce side effects, and provide powerful support for disease treatment.
Based on the professional GlycoNano™ Platform, our company offers a wide range of biological agents according to clients' research needs in different fields, if you can't find the biological agent you need, contact our researchers for biological agent production service.
Nucleic Acid Loaded Glyconanoparticle Formulation Service
Our researchers efficiently load DNA fragments, RNA molecules (e.g., miRNA, mRNA, siRNA, etc.), or other types of nucleic acids into glyconanoparticles. Moreover, we provide specific chemical modification services to improve their stability and biocompatibility.
Peptide Loaded Glyconanoparticle Formulation Service
Utilizing advanced technologies, our researchers load peptide drugs into glyconanoparticles to improve drug stability and bioactivity. According to the needs of the clients, we provide multiple types of peptide synthesis using enzymatic digestion, fermentation, genetic engineering, liquid phase peptide synthesis (LPPS), and solid phase peptide synthesis (SPPS).
Antibody Loaded Glyconanoparticle Formulation Service
Our company provides high-quality antibody-loaded glyconanoparticle formulation services. We precisely load antibody molecules into glyconanoparticles for targeted delivery and long-lasting release of antibodies, providing new solutions for immunotherapy.
Anti-HIV Prodrug Loaded Glyconanoparticle Formulation Service
Our company provides high-level anti-HIV prodrug-loaded glyconanoparticle formulation services. Our researchers use gold nanoparticles and carbohydrates containing anti-HIV prodrug candidates for designing efficient drug delivery systems. Moreover, we offer release site testing, glyconanoparticle characterization, and antiviral activity analysis.
Glycan Antigen Prodrug Loaded Glyconanoparticle Formulation Service
Our company provides high-performance glycan antigen prodrug-loaded glyconanoparticle formulation services such as GalNAc loading and SialylTn and Lewis y loading. Our researchers optimize the loading process and technical parameters to achieve efficient and stable loading.
Our company has a variety of techniques for synthesizing different types of glyconanoparticles, such as
Our researchers have extensive experience in biological agent loading. We ensure efficient and stable loading by precisely controlling the conditions (e.g. pH, ionic strength, etc.).
Our lab provides characterization and validation services for loaded glyconanoparticles including evaluation of size, shape, surface charge, loading efficiency, and biocompatibility. Moreover, it also includes their performance in real-world applications, such as cellular uptake efficiency, and gene expression levels.
Technology: Transmission electron microscopy (TEM), Dynamic light scattering method, Agarose gel electrophoresis, Laser Doppler microelectrophoresis
Journal: Pharmaceutics
Published: 2021
IF: 4.9
Results: In this study, researchers developed a mannose-modified cationic lipid nanoparticle (M-NP) to deliver the nucleic acid adjuvant and polycytidylic acid (PIC). Regardless of the molar ratio of the targeting ligand, the M-NP was able to fully load PIC as cargo. No significant changes in live cell density were observed after 24 and 48 h of cell incubation in the presence of PIC/M-NP with different mannose-PEG lipid contents. Nucleic acid adjuvants offer significant advantages in terms of biocompatibility and safety.
Fig.1 Characterization of PIC/M-NP. (Kim, et al., 2021)
Combining molecular synthesis and nanoscience, CD BioGlyco provides biological agent-loaded glyconanoparticle formulation services to clients around the world. Whatever type of biological agents you want to develop for glyconanoparticle formulation, We provide you with the most satisfactory solutions. Feel free to contact us.
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