The mechanism of glycosylation in cells involves a complex metabolic network composed of auxiliary proteins and enzymes. Altering the glycosylation structure or modifying the existing pattern of cell surface glycoproteins will affect the interaction and function of glycoproteins, mainly including genetic engineering, enzyme engineering, and chemical synthesis. The engineering provides precise control of cell surface glycoproteins and makes them have specific recognition, adhesion, signal conduction, or drug interaction, and then plays a key role in biological research, disease treatment, and drug study.
Fig.1 Overview of glycoengineering strategies. (Narimatsu, et al., 2021)
CD BioGlyco has the world's leading glycoengineering and protein technology platform and professional scientific research personnel, who are fully capable of providing clients with one-stop glycoengineering services.
Specific glycosyl structures are introduced or changed on cell surface glycoproteins using glycosyltransferases, and the glycosylation modification models of glycoproteins may be adjusted, affecting their interaction properties, such as N-glycoprotein-based cell surface glycoengineering service and O-glycoprotein-based cell surface glycoengineering service.
CD BioGlyco regulates the expression level of genes related to the glycosylation of cell surface glycoproteins by ways of gene editing, gene transfection, or gene knockout, thereby transforming the glycosylation state.
CD BioGlyco synthesizes sugar molecules with specific glycosyl structures and introduces them to the cell surface to achieve precise glycoengineering.
CD BioGlyco offers mature analysis and evaluation services-based cell surface glycoprotein glycosylation, including glycosylation site identification, glycosyl structure analysis, and glycoprotein interaction study, which help clients understand the glycosylation modification patterns and their impact on function and interaction.
CD BioGlyco also provides personalized glycoengineering solutions according to the client's specific needs and research goals.
These services help clients achieve precise control and regulation of cell surface glycoproteins, thereby promoting research progress in related fields.
Fig.2 One-stop cell surface glycoprotein glycoengineering services. (CD BioGlyco)
Cell surface glycoprotein glycoengineering is applied in many fields.
CD BioGlyco has accumulated rich experience and expertise in cell glycoengineering and integrated the most advanced technology to establish an efficient glycoengineering platform. Our platform provides high-level cell surface glycoprotein glycoengineering services with custom functions. Please feel free to contact us in time if you are interested in our services.
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