Applying Click Chemistry in Polysaccharide Conjugation

Click chemistry is an efficient, rapid, and selective chemical reaction for a wide range of substrates. Click chemistry reactions typically involve reactions with alkynes and azides, which rapidly form cyclic products of 1,2,3-triazacycles. This type of reaction is fast and mild and does not require initiators or special conditions, making it well-suited for conjugation reactions in polysaccharide chemistry. In the polysaccharide conjugation reaction, a polysaccharide is modified by a "click reaction" between a conjugate containing a specific chemical group and the polysaccharide. These groups can be small molecules, functional groups, or other reactive groups in the molecule. These reactions need to be achieved by certain chemical modification techniques to ensure the integrity and stability of the molecule. Through these reactions, various functional groups can be selectively introduced into different positions of polysaccharide molecules, thus imparting various chemical and physical properties to polysaccharides and expanding their applications in glycobiology and material science fields.

Click Chemistry-based Polysaccharide Conjugation Services at CD BioGlyco

CD BioGlyco uses state-of-the-art click chemistry to construct conjugated compounds of polysaccharides with various active molecules to achieve control and modification of various biologically important functions of polysaccharides. The specific services we offer include the following:

• Optimizing the properties of polysaccharide conjugate based on click chemistry
  We regulate the physical and chemical properties of polysaccharides, including solubility, molecular weight, thermodynamic stability, etc. By changing these properties, the drug properties of polysaccharides can be further improved, including the performance of absorption, distribution, and metabolism processes. Thus, the efficacy and safety of polysaccharide conjugations can be improved, providing important support for the development of new drugs.
• Polysaccharide selective conjugation by click chemistry
  We take advantage of the specificity of click chemistry to chemical structures and the controllability of reactions to achieve modifications on different positions of polysaccharides by selecting different chemical reagents and reaction conditions. This affects its physicochemical properties and biological activity.

Fig.1 Flowchart of click chemistry-based polysaccharide conjugation. (CD BioGlyco)

Applications

• Labeling and tracking of specific types of cells
• Preparation of vaccines
• Improving the water solubility of drugs

Advantages of Us

• Mild reaction conditions
• First-class technology platforms Well-trained researchers
• Well-trained researchers

CD BioGlyco specializes in providing One-stop Solutions for Polysaccharide Conjugation service based on various Technologies including click chemistry methods to our clients. Our experts have many years of experience in click chemistry and we provide customized polysaccharide conjugation compound design and production services based on your needs. If you are interested in our services, please feel free to contact us for more details.

Reference:

1. Meng, X.; et al. "Click" reactions in polysaccharide modification. Progress in Polymer Science. 2016, 53: 52-85.