FGFR inhibitor BMS-540215, Purity ≥98%

Synonym: 649735-46-6; FGFR inhibitor; BMS540215

MDL: MFCD13194684
CAS Number: 649735-46-6
Compound CID: 11234052

Product Size

5 mg; 10 mg; 50 mg; 200 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

BMS-540215, soluble in DMSO and ethanol and insoluble in water, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against FGFR. It targets FGFR1, Flk1, EGFR, JAK3, LCK, PDGFRβ, PKCα, VEGFR1, and VEGFR2.

Molecular Weight

370.4

Molecular Formula

C₁₉H₁₉FN₄O₃

Targets

FGFR1: 148 nM; Flk1: 89 nM; EGFR: >1.9 μM; JAK3: >50 μM; LCK: >2.5 μM; PDGFRβ: >6 μM; PKCα: >25 μM; VEGFR1: 380 nM; VEGFR2: 25 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 71 mg/mL (191.69 mM); Water: Insoluble; Ethanol: 3 mg/mL (8.09 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

BMS-540215 is used in FGFR research to explore its importance in tumorigenesis and potential treatment.