Description
TKI-258, soluble in DMSO and insoluble in ethanol and water, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against FGFR. It targets c-Kit, FGFR1, c-Met, CSF-1R/c-Fms, EGFR, EphA2, FGFR3, FLT3, HER2, IGF-1R, and Insulin receptor.
Applications
TKI-258 is employed in the exploration of FGFR, aiding in cancer research by inhibiting FGFR, particularly in tumors with FGFR pathway dysregulation.
