FGFR inhibitor TKI258 dilactic acid, Purity ≥98%

Synonym: 852433-84-2; FGFR inhibitor; CHIR-258; TKI258

CAS Number: 852433-84-2
Compound CID: 135985126

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

TKI258 dilactic acid is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against FGFR. It targets c-Kit, FGFR1, c-Met, CSF-1R/c-Fms, EGFR, EphA2, FGFR3, FLT3, HER2, IGF-1R, and Insulin receptor.

Molecular Weight

572.6

Molecular Formula

C₂₁H₂₁FN₆O.2C₃H₆O₃

Targets

c-Kit: 2 nM; FGFR1: 8 nM; c-Met: >3 μM; CSF-1R/c-Fms: 36 nM; EGFR: 2 μM; EphA2: 4 μM; FGFR3: 9 μM; FLT3: 1 μM; HER2: >10 μM; IGF-1R: >10 μM; Insulin receptor: 2 μM

Form

Lyophilized powder

Purity

≥98%

Identity

Confirmed by NMR/HPLC/MS.

Applications

TKI258 dilactic acid is utilized to study FGFR in the context of its role in cancer, providing a research tool for exploring FGFR-targeted therapies.