Strive to Create Quality Services

CD BioGlyco is committed to building a leading glycogene engineering service. To this end, we specialize in building highly executive and experienced research teams. We have a wide variety of Technologies for Gene Editing. We regulate the expression of glycogene through overexpression, knockdown, knock-in, knockdown, and many other Strategies. Based on our vast experience, we achieve one-stop technical service solutions for gene editing, bioinformatics, pharmacology, efficacy, etc.

Fig.1 One-stop glycogene editing service. (CD BioGlyco)

• Glycogene Editing Service
  Glycosylation is a common post-translational modification that occurs in the Golgi apparatus and endoplasmic reticulum. The process is coordinately regulated by glycogenes such as glycosyltransferases, glycosidases, nucleotide sugar synthesis, and transport, etc. Glycogene is a group of genes encoding glycosyltransferases, glycosidases, and other glycan-related genes. Our glycogene editing service is aimed at research partners in various fields such as animal, plant, and microbiology. Glycosylation plays important functions in cells and organisms. It is involved in regulating important biological processes such as cell recognition, adhesion, and signal transduction. Abnormal glycosylation leads to inflammation, tumors, and other diseases. We are committed to influencing the glycosylation process by regulating the expression of glycogene. We also analyze the correlation between various glycosyltransferases, glycosidases, etc., and the occurrence of diseases. We aim to find new targets for disease treatment. We also expand the application of glycosyltransferases, glycosidases, etc., by heterologous expression of target proteins with functional properties.
• Technologies for Gene Editing
  We have mature technologies for gene editing, including transcription activator-like effector nucleases (TALEN) technology, CRISPR/Cas9 technology, zinc-finger nucleases (ZFN) technology, etc. We use technologies for gene editing to produce cell lines, animal models, and many other expression systems. Our services include metabolic engineering modifications, apoptosis regulation, inhibition of cancer cell migration, and many other types of services.

Fig.2 Advantages for gene editing. (CD BioGlyco)

Applications

• Validation of the functions of various glycosyltransferases in plants, microorganisms, etc.
• Synthesis of glycosyltransferases with specific functions.
• Study of the application of glycosyltransferases in the treatment of diseases.

Advantages

• Our technical team has rich experience in gene editing and provides complete technical solutions for CRISPR gene editing projects.
• We edit a rich variety of glycogene, with a high success rate of gene editing, a short experimental period, and other advantages.
• The technologies for glycogene editing help to find new therapeutic targets or disease markers for disease treatment.

CD BioGlyco provides high-quality glycogene engineering transformation services for biological research enterprises, scientific research institutes, etc. In addition, we also provide a Cancer Glycogene Discovery Service. Please feel free to contact us with any questions.

Reference:

1. Kelkar, A.; et al. Forward genetic screens of human glycosylation pathways using the glycogene CRISPR library. Curr Protoc. 2022, 2(4): e402.