CD BioGlyco offers specialized 3D printing production services with GlycoNano™ Bioink, delivering precision and versatility for your projects. Dedicated to enhancing accuracy, safety, and biological functionality, our solution drives research towards groundbreaking clinical and therapeutic advancements.
Get a Quote NowThe field of tissue engineering (TE) and regenerative medicine has seen a surge in interest in 3D bioprinting due to its potential to create functional tissue and organ surrogates that closely mimic native structures with high reproducibility. While techniques like electrospinning and freeze-drying have been explored, 3D bioprinting offers superior control over construct properties, enhanced versatility, and improved reproducibility. The main challenge lies in developing bioinks—materials that combine with cells and other components to be precisely arranged in a hierarchical and spatially organized manner. However, the printing conditions that maintain cell viability often differ from those needed for high-resolution structures, complicating the production of customized constructs. To overcome these obstacles, CD BioGlyco provides bioink production service for 3D printing that is centered around the production of advanced bioinks formulated from glycan nanomaterials, designed specifically for 3D bioprinting applications.
We use advanced glycan nanomaterials to create bioinks that closely mimic native tissue environments, enhancing cell functionality and tissue integration. Our service provides customized bioinks tailored to specific tissue types and applications, with precise control over mechanical properties, porosity, and biochemical cues. By combining these bioinks with state-of-the-art 3D bioprinting technologies, we ensure high-fidelity fabrication of complex tissue architectures, advancing the field of tissue engineering and regenerative medicine. Our service includes two main components:
GlycoNano™ Carbohydrate Base Material Bioink Production Service
Carbohydrate-based materials are highly biocompatible and biodegradable, making them ideal for tissue engineering applications. Our research team offers customizable carbohydrate-based bioinks that can be tailored to meet specific rheological properties, mechanical performance, and biological activity. These bioinks are suitable for printing complex 3D structures and support cell proliferation and differentiation, providing an ideal environment for tissue repair and regeneration.
GlycoNano™ Tissue-specific Bioink Production Service
We design bioinks with tailored mechanical properties, degradation rates, and biological activity to mimic the microenvironment of specific tissues. These bioinks promote functional cell behavior within the printed structures. For example, bioinks for soft tissues (such as skin and blood vessels) and hard tissues (such as bone and cartilage) have different formulations and physical properties to meet their specific biological and structural requirements.
We carefully analyze the client's requirements, including the target application, preferred materials, and functional properties, and then design the bioink formulation by selecting appropriate biomaterials and bioactive factors, ensuring optimal composition ratios. Developing a cell-friendly gelation mechanism is crucial to maintaining cell viability and function post-gelation, while also ensuring a homogeneous distribution of cells, particles, or fibers within the biomaterial to prevent sedimentation issues.
Biocompatibility testing is conducted to confirm that the bioink materials are non-toxic and support cell growth. Additionally, the degradation and swelling behavior of the materials are studied to understand their effects on geometric accuracy and structural stability, ensuring they meet the necessary performance criteria for 3D bioprinting.
We measure the rheological properties of the bioink, such as viscosity and flow behavior, to predict its printability and shape fidelity. For extrusion printing assessments, evaluate the bioink's extrudability, filament formation, and mechanical stability; whereas for lithographic printing assessments, optimize light penetration and depth of photocuring to ensure precision and shape fidelity.
Based on the rheological and printability assessments, key printing parameters such as print speed, layer height, and temperature are fine-tuned to optimize the printing process. Advanced imaging technologies are used for real-time monitoring of the printing process, ensuring the quality of each layer and the overall integrity of the 3D constructs.
We evaluate the viability, proliferation, and differentiation of cells within the printed structures to confirm that the bioink supports normal cell growth and function. Additionally, the remodeling of the extracellular matrix is assessed to ensure it supports advanced cell functions, meeting the requirements for biological applications.
Whenever the bioink composition, gelation mechanism, or photoinitiator is altered, the entire workflow is reassessed to ensure it meets the criteria for a cell-friendly environment and optimal printability. This iterative improvement process ensures that the bioink continues to perform effectively in various bioprinting applications.
By following these steps, the GlycoNano™ bioink production service for 3D Printing ensures that the bioink is optimized for both printability and biological performance, meeting the specific needs of the client's application.
DOI: 10.1186/s40824-018-0122-1
Journal: Biomaterials research
Published: 2018
IF: .8.1
Result: The research at hand delves into the cutting-edge developments in polymer-based bioinks tailored for 3D bioprinting, with a particular emphasis on their role in tissue engineering and regenerative medicine. The study meticulously examines the critical attributes necessary for the effective selection of bioinks, encompassing biocompatibility, printability, and mechanical resilience. Furthermore, it investigates the synergistic integration of cells, biomedical polymers, and biosignals to engineer functional 3D tissue and organ constructs. The review underscores the emergence of highly adaptable bioinks that exhibit compatibility with live cells, superior printability, and sustained mechanical integrity post-printing, facilitated by the judicious use of functional polymeric biomaterials, their modifications, and the blending of cells with hydrogels. These innovations underscore the promising potential of these bioinks in the creation of increasingly intricate tissue and organ structures via 3D bioprinting technology.
At CD BioGlyco, we provide advanced bioink solutions that leverage glycan nanomaterials to closely mimic native tissue environments, enhancing cell functionality and tissue integration. Starting from material and formulation development, through biocompatibility and performance assessments, printability evaluations, and printing parameter optimization, to biological performance assessments and iterative optimization, this comprehensive process ensures the bioink's optimal performance in both printability and biological functions, meeting the unique requirements of the client's application. If you have any questions or would like to inquire about our GlycoNano™ Platform, please don't hesitate to contact us. Our team of experts is here to provide you with the information and support you need to make informed decisions about your research and development projects.
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