Biofabrication encompasses the automated production of structurally organized, biologically functional products through the integration of bioactive molecules, living cells, and cell aggregates—including micro-tissues, biomaterials, or hybrid constructs of cells and materials—via processes such as bioassembly or bioprinting, culminating in subsequent tissue maturation. The emergence of 3D bioprinting as a novel biofabrication approach has been particularly noteworthy, offering enhanced control over the architectural organization of printed tissue constructs, a feature largely attributable to the automated deposition process, which confers high reproducibility. Across the bioprinting strategy, the bioink remains a critical component, requiring stabilization or cross-linking during or immediately post-printing to achieve the desired tissue construct shapes. Therefore, CD BioGlyco provides an advanced Platform for offering the Bioink Production Service where the choice of bioink depends on the intended application, such as target tissue.
The process of our GlycoNano™ tissue-specific bioink production service is meticulously designed to tailor bioinks to the specific requirements of the target tissue. Here's a detailed description of the process:
Computer-aided design (CAD) and computer-aided manufacturing (CAM) tools are employed to construct the corresponding 3D structure of the scaffold. These technologies allow for precise customization of the scaffold to match the specific tissue geometry.
The composition of the bioink is carefully formulated, taking into account the desired characteristics specified in the property requirements of bioinks/scaffolds. Common materials we use include chitosan, alginate, carrageenan, and so on. Cells encapsulated within the bioink can be derived from autologous or allogeneic sources, ensuring that the bioink is both biocompatible and capable of promoting cell growth and differentiation.
Each batch of bioink undergoes rigorous quality control to ensure it meets the required biocompatibility, mechanical properties, and cell viability. The bioink is tested in vitro to assess its performance in supporting cell growth and differentiation, as well as its compatibility with the intended tissue type.
GlycoNano™ Skin Bioink Production Service
In CD BioGlyco, we design various bioink formulas to produce highly specialized bioinks tailored for specific tissue engineering applications. These bioinks are formulated to mimic the unique structural and functional characteristics of various human tissues, making them essential for 3D bioprinting in regenerative medicine and tissue engineering.
GlycoNano™ Bone Bioink Production Service
Our bioinks are specifically designed to mimic the unique mineralized structure and properties of natural bone tissue. They effectively promote bone cell differentiation and mineralization, making them ideal for applications in bone defect repair, orthopedic research, and testing the biocompatibility of implants. Through our innovative approach, we aim to enhance treatments and outcomes in the field of bone regeneration and repair.
GlycoNano™ Cardio Bioink Production Service
We offer a specialized cardio bioink production Service for cardiovascular tissue engineering. Our bioinks are designed to mimic the mechanical properties and microarchitecture of cardiac tissue, incorporating cardiomyocyte-supportive ECM components and cardiac-specific growth factors. These features facilitate the generation of functional cardiac tissue models, making them ideal for studying heart disease progression, drug toxicity screening, and developing cardiac repair strategies.
GlycoNano™ Hepar Bioink Production Service
We specialize in producing hepar bioinks for liver tissue engineering applications, supporting hepatocyte function, including metabolic processes and drug detoxification, making them ideal for modeling liver diseases, studying drug metabolism, and exploring liver regeneration strategies. Through our commitment to innovation and quality, we strive to advance the field of liver regenerative medicine and improve treatments for liver-related conditions.
DOI: 10.18063/IJB.2016.01.009
Journal: International Journal of Bioprinting
Published: 2016
IF: .6.8
Result: In this study, authors optimized polyelectrolyte gelatin-chitosan hydrogels for 3D bioprinting by addressing the poor printability and long crosslinking times of collagen-based materials. Chitosan, known for its antimicrobial and hemostatic properties, is modified by combining it with oppositely charged functional groups from gelatin at a pH of 6.5 to form polyelectrolyte complexes. The hydrogels were evaluated for physical interactions, rheological properties, printing resolution, and biocompatibility with fibroblast skin cells. The results show that the optimized hydrogels are suitable for 3D bioprinting at room temperature, achieving high shape fidelity and good biocompatibility, making them promising for wound healing and tissue engineering applications.
At CD BioGlyco, through a comprehensive process, we ensure the production of high-quality, customized bioinks that are perfectly suited for the regeneration of various tissues. Whether you require bioinks for skin, bone, cardiovascular, or liver tissue engineering, contact us to obtain tailored solutions that accelerate your research and bring you closer to achieving successful tissue regeneration.
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