Clear Solutions for Hydroxypropyl Cellulose (HPC) Analysis

HPC is a non-ionic cellulose ether prepared by reacting basic cellulose with propylene oxide under high temperature and pressure. It is divided into Low-substituted Hydroxypropyl Cellulose (L-HPC) and high-substituted hydroxypropyl cellulose (H-HPC) depending on the content of the substituent hydroxypropoxy groups. HPC is a good thermoplasticity, adhesion, and film-forming agent that can be used in the manufacture of adhesives and films that are capable of being combined with other pharmacological excipients for a broad range of applications.

At CD BioGlyco, we have conducted in-depth research in the field of Pharmaceutical Excipients, and provide our clients with custom HPC analysis solutions and professional services.

• Identification
  • An aqueous solution of HPC reacts with a sulphuric acid solution of anthrone to produce a blue-green substance.
  • The slurry liquid formed when HPC is added to water forms a film on a glass plate.
  • The solution formed by adding water to HPC shows a flocculent precipitate when heated, and this precipitate dissolves when the temperature is lowered.
• Basic characteristics
  HPC is a white or off-white powder or granule that swells to form a colloidal solution in water, ethanol, or propylene glycol, but hardly dissolves in hot water.
• Content detection
  We use gas chromatography (GC) to determine the amount of HPC in the samples. The amount of HPC can be determined by the area of the peaks in the obtained GC.
• Viscosity
  After making a solution of HPC at a specific concentration, we choose a rotational viscometer to determine the viscosity value of HPC.
• pH
  After heating-cooling the HPC solution, we use a pH meter to check its pH value, which should be between 5.0 and 8.0.
• Chlorides
  Chlorides usually react with silver nitrate to form a precipitate. Therefore, we add silver nitrate solution to a dilute solution of HPC and observe whether a white precipitate is produced to determine the presence of chlorides in HPC.
• Residual solvents (isopropanol and toluene)
  GC: The GC of HPC is tested using cyanopropylphenyl-dimethylpolysiloxane as a stationary solution. Using the external standard method, isopropanol and toluene quantities can be determined by reference to peak area.
• Scorch residue
  The residue of HPC should not exceed 0.8% of the weight of the dried HPC after sufficiently cauterizing the HPC.

Applications

• Pharmaceutical R&D: In pharmaceutical formulations, HPC has the function of promoting drug solubility and stability. HPC analysis services can help researchers better understand the nature and properties of HPC to ensure the quality and stability of pharmaceutical formulations.
• Cosmetics: HPC is often used as a thickener, emulsifier, and stabilizer in the manufacture of cosmetics. Analysing HPC can help researchers ensure product quality, improve formulations, and rationalize the use of the ingredients.
• Food Processing: HPC is used as a thickener and stabilizer in food processing to enhance the taste and texture of food. Understanding the levels and properties of HPC through analysis services can help control quality and stability during food production.

Advantages

• We have advanced Pharmaceutical and Biological Evaluation technologies to ensure high quality and efficient completion of HPC analysis.
• Our HPC analysis protocols undergo rigorous quality testing to ensure that we provide our clients with reliable HPC analysis protocols and results.
• We provide timely feedback to our clients on the progress of HPC analysis experiments to ensure their participation.

CD BioGlyco has extensive expertise in the field of pharmaceutical analysis. We not only provide our clients with custom HPC analysis services but also provide detailed data interpretation. Clients are encouraged to contact us as we eagerly look forward to the opportunity to assist our clients.