Principle of Ionic Crosslinking-based Polysaccharide Conjugation

Ionic crosslinking refers to the joining of molecules together to form a crosslinked network through ionic bonding or electrostatic interactions. In ionic crosslinking, two or more charged ions come close together and combine to form a sparse structure. Ion crosslinking occurs either in solution or in solids. In solution, when ions with opposite charges are close to each other, the electrostatic interactions between them lead to ionic cross-linking and the formation of ionic gels or micelles. Ionic crosslinking-based polysaccharide conjugation reactions are a widely used method for polysaccharide modification. The polysaccharides are cross-linked with other molecules by ionic crosslinking agents to achieve functionalized modification. In this reaction, polysaccharides form a cross-linked network by binding charged functional groups to ions in the ionic crosslinker. The ionic cross-linking agents form electrostatic interactions with the functional groups in the polysaccharide by the mutual attraction of charges, which triggers the reaction. The ionic cross-linked polysaccharide conjugation enables a variety of functions, such as increasing the stability of polysaccharides, improving their solubility, and regulating the rate of drug release.

Ionic Crosslinking-based Polysaccharide Conjugation Services at CD BioGlyco

With the wide application of polysaccharide conjugates in the fields of medicine and material, the development of various methods for polysaccharide conjugation is essential. CD BioGlyco has established a Glyco™ Vaccine Development Platform to offer professional Polysaccharide Conjugation services based on a wide range of Technologies, including ionic crosslinking-based methods:

• Electrostatic crosslinking service
  Functional groups in the polymer interact electrostatically with charged ions (e.g., cations or anions) in solution to form crosslinks.
• Metal ion crosslinking service
  We form cross-linked structures through electrostatic interactions or coordination between metal ions and polymers. It allows a relatively fast and facilitates the efficient crosslinking process.
• Ionic liquid crosslinking service
  We use ionic liquids as a medium to achieve crosslinking reactions of the conjugates through ionic conductivity and tunability. We strive to provide highly flexible and adjustable crosslinking services for crosslink modification and functional adjustment of various conjugate systems.

Fig.1 Ionic crosslinking-based polysaccharide conjugation. (CD BioGlyco)

Applications

• Drug delivery system
• Preparation of biocompatible materials
• Coating of medical devices

Advantages of Us

• High stability and resistance to hydrolysis
• Adjustable reaction rate and extent of cross-linking
• Attentive and dedicated service

CD BioGlyco provides expert advice and solutions to help our clients achieve their research and application goals in the field of polysaccharide conjugation. We are dedicated to providing our clients with efficient ionic crosslinking-based polysaccharide conjugation services. If you need any further information, please feel free to contact us and we will respond immediately.

Reference:

1. Lapitsky, Y. Ionically crosslinked polyelectrolyte nanocarriers: Recent advances and open problems. Current opinion in colloid & interface science. 2014, 19(2): 122-130.