Meglumine, also known as 1-anhydro-D-fructosamine, is an amino alcohol sugar commonly employed in medicine and pharmacy as a delivery medium or imaging agent. It possesses the ability to enhance solubility and improve the availability of certain drugs or chemicals when combined with them within the body. For instance, meglumine finds application in the formulation of X-ray contrast agents like iobenguane. Therefore, it is crucial to conduct precise Pharmaceutical Analysis of meglumine, as this directly impacts drug quality control, efficacy evaluation, and clinical safety. CD BioGlyco has effectively analyzed a diverse range of intricate pharmaceutical compounds, encompassing Magnesium Gluconate Analysis Service, Manganese Gluconate Analysis Service, and meglumine analysis service. Our meglumine analysis services include but are not limited to:
Fig.1 Meglumine analysis service. (CD BioGlyco)
Technology: HPLC
Journal: Journal of Pharmaceutical and Biomedical Analysis
IF: 3.4
Published: 2018
Results: This article investigated the use of HPLC for the determination of meglumine by-products that could be present in the meglumine samples in pharmaceutical formulations. The researchers tried four different approaches to develop an HPLC method, including HPLC analysis of metamidoguanidine before derivatization, the use of ion-pair reagents in the mobile phase, the use of a charged surface-hybridized stationary phase, and the use of a column used for the separation of carbohydrates. The results showed that the method using anion-pair reagents in the mobile phase was suitable for the quantitative determination of metamidoguanidine in solid dosage forms. The HPLC separation was performed on an Agilent Eclipse XDB-C18 column using a mobile phase containing octane-1-sulfonic acid. The method was validated and the validation included studies of selectivity, precision (reproducibility), linearity, and accuracy. RID and DAD detectors were used in the validation experiments.
Fig.2 Structure of meglumine. (Svard, et al., 2016)
CD BioGlyco offers personalized meglumine analysis services tailored to meet your specific requirements, ensuring optimal time and cost savings without compromising on efficiency. If you have any questions about our company and services, please feel free to contact us.
References