Characterization of Cytosine Nucleoside

Cytidine is a chemical substance with the molecular formula C₉H₁₃N₃O₅. It is a ribonucleoside (containing the pyrimidine base cytosine) that makes up nucleic acids and forms a unit of the genetic code. Cytidine pairs with the corresponding guanosine in a non-covalent form in deoxyribonucleic acid and ribonucleic acid. Cytidine, as an important component of RNA in the human body, plays an important regulatory role in organisms and has a variety of physiological activities. Cytisine is also a good raw material for many anti-viral, anti-tumor, and anti-AIDS drugs. In addition, Cytidine derivatives can improve the state of consciousness and electroencephalogram after head trauma as well as brain surgery, and it is useful in promoting the recovery of brain function and awakening.

Fig.1 Metabolic network for the production of cytidine from glucose in Escherichia coli. (Yang & Li, 2020)

Nucleoside-based Cytidine Production Service at CD BioGlyco

The role of cytidine in the medical field is crucial. For the production of cytidine, CD BioGlyco has extensive experience. We offer a variety of ways to choose from in terms of production routes.

• Chemical Synthesis
  This method mainly takes other base fragments as raw materials and obtains cytidine through a series of catalytic reactions. In the chemical synthesis method, there are abundant routes, and CD BioGlyco uses microwave radiation in this method, and adjusts the routes according to the application range of the target products to produce the most suitable cytidine for customers.
• Ribonucleic acid hydrolysis
  This method takes ribonucleic acid as the substrate, hydrolyzes it with the catalytic effect of the enzyme, and finally separates and purifies it to get cytidine. The conditions of this method are mild, and it is an excellent way to produce cytidine.
• Biological fermentation
  We apply molecular biotechnology to the cultivation of cytidine fermentation strains to maximize the production of cytidine. This method has a short cycle time, simple conditions, and high yield, which is very suitable for industrialized production of cytidine.

Fig.2 Production methods of cytidine. (CD BioGlyco)

Applications

• Cytosine could be used to develop anti-tumor drugs.
• Cytosine could be used as an adjunct to study the treatment of AIDS.
• Cytosine could be used in the research of leukemia treatment.
• Cytosine could be used in the development of antiviral drugs.

Advantages

• We have a wide range of cytidine production routes to provide custom and professional services to our clients.
• Cytidine has better efficacy in tumors as well as AIDS, so its production services help researchers study the mechanism of these diseases.

CD BioGlyco customizes different production solutions according to the different research needs of our clients. The optimization methods we use solve most of the disadvantages of synthetic cytidine and provide the best quality products for our client's research. If you are interested in our services, please feel free to contact us for more details.