Characteristics of Cytosine

Cytosine, also known as 4-amino-2-carbonylpyrimidine, is an organic substance with the molecular formula C₄H₅N₃O. It is one of the major base components in nucleosides. Cytosine is usually synthesized from mercapturic uracil, concentrated ammonia, and chloroacetic acid. Its molecular formula mainly has two isomeric forms: ammonia-ketone type and ammonia-enol type, and it usually exists formerly at room temperature and normal pressure. Cytosine is an important intermediate for synthetic chemicals, pesticides, and pharmaceuticals. In agriculture, cytosine is used as a raw material for the synthesis of cytosine nucleoside peptides, which are highly efficient and low-toxic pesticides and antibiotics. In the field of medicine, cytosine is mainly used in the synthesis of anti-AIDS drugs, drugs for the treatment of chronic hepatitis B, and antifungal drugs. It can also be applied to produce intermediates for fine chemicals. Therefore, cytosine has a broad development prospect, and its production and application research is very urgent.

Fig.1 Chemical structural formula of cytosine. (CD BioGlyco)

Nucleoside-based Cytosine Production Service at CD BioGlyco

CD BioGlyco offers a full range of services in the production and structural characterization of cytosine. Cytosines are also used as intermediates in pharmaceuticals, fine chemicals, pesticides, and so on.

For the synthesis of cytosine, CD BioGlyco provides the following two Chemical Synthesis methods:

• The functional group conversion method
  We use pyrimidines as starting materials and obtain cytosine through a series of chemical reactions in organic solvents. During this process, we obtain cytosine with fewer impurities by protecting the functional groups. CD BioGlyco also screens catalysts and organic solvents to obtain optimal reaction conditions.
• Pinner method
  The starting materials for this method are mainly acrylonitrile/acrylonitrile derivatives or analogs, and urea and its analogs. In this process, we first obtain the cytosine salt and then hydrolyze it under catalyst conditions to obtain cytosine. At CD BioGlyco, the yield of cytosine obtained by this method reaches more than 70%.

Secondly, we offer qualitative and quantitative analysis of cytosine.

Qualitative analysis is performed by elemental analysis, UV spectroscopy, mass spectrometry, X-ray powder diffraction, TG, IR, and NMR. Quantitative analysis is performed by HPLC.

Fig.2 Production and analytical methods of cytosine. (CD BioGlyco)

Applications

• Cytosine is used in antibiotic production studies for pesticides.
• Cytosine is used in antitumor and antiviral drug development.
• Cytosine is used in the production research of analgesic drugs.

Advantages

• We have a wide range of cytosine synthesis routes that help researchers to study efficiently.
• Cytosine production services help in exploring its structure and function in depth.
• Cytosine production helps in analyzing the structure of cytosine nucleosides.

CD BioGlyco has a specialized research platform with a long-term commitment to cytosine production. We will meet the production needs of our clients. If you are interested in our services, please feel free to contact us promptly.