The Role of Deoxythymidine Derivatives in Disease Treatment Studying

Due to their structural similarity to the composition of nucleic acids, and nucleoside analogs. Their derivatives have shown significant superiority in the study of novel anticancer drugs. 3'-Azido-3'-deoxythymidine (AZT) is a deoxythymidine analog. It is converted to mono-phosphoryl AZT, bis-phosphoryl AZT, and tri-phosphoryl AZT by cellular kinases. Then tri-phosphoryl AZT is embedded in the synthesis chain of viral DNA to terminate the synthesis of viral DNA. In addition, scientists find that the ultraviolet absorption wavelength changes when the oxygen atom at the 4-position of thymidine is replaced by a sulfur atom. The compound shows extreme sensitivity to long-wave ultraviolet light and is susceptible to photochemical reactions under near-ultraviolet radiation. Studies have shown that 4-thiothymidine can selectively target cancerous cells and tissues. It embeds itself in the form of nucleotides into the DNA of target cells, making it more sensitive to near-ultraviolet light (UVA); it kills cancerous cells under the action of near-ultraviolet light.

Fig.1 The structure of AZT. (Wikipedia)

Nucleoside-based Deoxythymidine Derivative Production Service at CD BioGlyco

CD BioGlyco provides custom deoxythymidine derivative production services for specific samples and needs. Based on our comprehensive understanding of various synthetic chemistries, we will perform challenging constructs with excellence.

• Deoxythymidine derivative production services

Deoxythymidine analogs currently used to treat HIV and cancer have more pronounced toxic side effects. In order to reduce the toxic side effects and improve the antiviral activity of the drugs, it is necessary to develop and synthesize new deoxythymidine derivatives. We produce novel deoxythymidine derivatives mainly by chemical method. We will determine the optimal feed ratio to ensure an easier separation process of the product.

4-Thiodeoxythymidine offers a new direction for the research of the treatment of cancer. Three effective methods are used to convert thymidine analogs to 4-thiothymidine analogs: the phosphorus pentasulfide method, Lawesson's reagent method, and the triazole method. We successfully produce 4-thiothymidine analogs by these three methods. According to clients' requirements, we will design a reasonable route to prepare 4-thiodeoxythymidine derivatives.

• Deoxythymidine derivative products

Through continuous attempts, we have identified the best production route for some of the deoxythymidine derivatives. We supply deoxythymidine derivative products in small sizes. Our products include the following.

Fig.2 Types of deoxythymidine derivative products. (CD BioGlyco)

Applications of Deoxythymidine Derivative Production Service

• Modification of deoxythymidine analogs is of great significance and practical value in the fields of chemistry and life sciences.
• The introduction of biologically active molecules into deoxythymidine drug molecules with antiviral activity is of great significance in the search for novel and efficient antiviral chemical entities.
• The design and production of novel deoxythymidine analogs are expected to be a new approach to disease diagnosis.

Advantages

• Base and structure play an important role in the biological activity of nucleoside analogs. Modification of deoxythymidine helps to produce substances with a wide range of biological activities.
• Our production facilities are well-equipped and our production methods are flexible. Our excellent production capabilities enable us to meet customized requirements.
• Our purification process is optimized and enhanced. Our products are low in salt content and cytotoxicity.

CD BioGlyco aims to provide an experimental basis for the design and production of novel deoxythymidine-based anti-cancer drugs, screening of target drugs, utilization, modern production of drugs, etc. In addition, we also provide Nucleoside-based Deoxyuridine Derivative Production Service and Nucleoside-based Dideoxynucleotide Derivative Production Service. If you want to know more about deoxythymidine derivative production, please feel free to contact us.