Nucleoside-based Deoxyuridine Derivative Production Service at CD BioGlyco

CD BioGlyco aims to provide data support for the large-scale industrial production of the Deoxyuridine derivative. We try various routes to screen the production of various deoxyuridine derivatives under mild reaction conditions, high stereoselectivity, and easy operation.

Fig.1 The production process of deoxyuridine derivative. (CD BioGlyco)

• Deoxyuridine derivative production service

We mainly produce deoxyuridine derivatives by Chemical and Enzymatic Methods. The advantage of chemical synthesis is that it can produce deoxyuridine derivatives with novel structures and potential biological activity. We produce deoxyuridine derivatives using uridine as raw material through various chemical reactions. The enzymatic synthesis also has more advantages, such as the ability to produce a single structure product, the convenience of isolation, etc. We catalyze the production of deoxyuridine derivatives by purified enzymes, including nucleoside phosphorylase and N-deoxyribosyltransferase. In addition, we also select strains with strong enzyme activity as the source of the enzyme to catalyze the production of deoxyuridine derivative. In order to increase the yield, reduce the cost of production, etc., we produce deoxyuridine derivatives with other compounds as raw materials. We also have complete testing instruments. After the production, we analyze the structure by infrared spectroscopy, mass spectrometry, HPLC, NMR spectroscopy, and so on. Based on our rich experience in various productions, we will fulfill the requirements of our clients.

• Deoxyuridine derivative products

• 2'-Deoxy-β-uridine.

2'-deoxy-β-uridine is an important pharmaceutical intermediate. It is used for the preparation of antiviral drugs, antitumor drugs, and other active compounds. Through optimization, we avoid the problems of cumbersome steps, poor safety, single-product, brominated impurities affecting product quality, etc., which are caused by using uridine as raw material.

• 5-Fluoro-2'-deoxyuridine

It has the advantages of low cytotoxicity and easy absorption in the body. It affects DNA synthesis by inhibiting thymine deoxyribonucleotide synthetase and blocking the conversion of uracil deoxyribonucleotides to thymine nucleotides. 5-Fluoro-2'-deoxyuridine has antiviral replication and antitumor effects. Enzymatic synthesis has great advantages in terms of its high efficiency, mild reaction conditions, and single-product structure. We screen strains with strong nucleoside phosphorylase activity as the source of enzyme and produce 5-fluoro-2'-deoxyuridine enzymatically.

• In addition, we also produce Other Deoxyuridine Derivatives.

Applications of Nucleoside-based Deoxyuridine Derivative Production Service

• Modification of deoxyuridine enables the production of deoxyuridine derivatives with different structures, which are important in the study of drug resistance mechanisms.
• A wide range of deoxyuridine modifications are used for the study of its antitumor, antiviral, and other activities.
• The optimized deoxyuridine derivative production technique is used for the synthetic studies of fluorescein-labeled compounds.

Advantages

• We implement strict standardized management of all processes from raw materials, production, and testing to ensure product quality and batch-to-batch stability.
• We have optimized the conditions for the production of the deoxyuridine derivative. The reaction conditions are mild. It is easy to separate and purify the product after production. deoxyuridine derivative has a high yield.
• We are well-equipped for structural analyses, and biophysical studies such as NMR and X-ray crystallographic studies are possible.

CD BioGlyco provides high-quality custom production services of deoxyuridine derivatives. Our products undergo strict quality control and validation. We are equipped with professional medicinal chemists and biologists to meet our clients' production requirements. If you have any questions about deoxyuridine derivative production, please feel free to contact us.