Nucleoside-based Different Backbone Sugar-based Derivative Production Service

Client Satisfaction Is Our Goal

CD BioGlyco focuses on the study and production of various nucleoside derivatives. The biological activity of nucleoside derivatives is closely related to the Sugar moiety. The modification of the sugar moiety is used to screen out drugs with higher activity, improve the efficacy and pharmacological properties of known drugs, reduce the toxic side effects, etc. Most of the clinically used nucleoside analogs are glycosyl-modified derivatives. We conduct various modification studies on nucleoside glycosyl groups. Our products include a range of products such as aglycone riboside.

Fig. 1 Processes for sugar-based nucleoside modification. (CD BioGlyco)

• Cytarabine production service at CD BioGlyco

Cytarabine, a combination of arabinose and Cytosine, has antibacterial, antiviral, and anticancer activities, etc. It slows down or inhibits cell proliferation by inhibiting DNA synthesis and is mainly used as an antimetabolic drug in research. Currently, there are two main methods to produce cytarabine. One is to produce cytarabine from D-ribose. This method has a low yield. The other is to produce cytarabine by cyclization and hydrolysis with cytidine as raw material. This method has certain hazards. In order to serve the disadvantages of expensive raw material cost, high reagent toxicity, and low yield, we design and optimize a new route of production using the production of nucleoside analogs as a reference. We will also chemically modify the non-pharmaceutically active functional groups of p-cytidine.

• 9-β-D-arabinofuranosyladenine production service at CD BioGlyco

9-β-D-arabinofuranosyladenine is a broad-spectrum DNA viral inhibitor that interferes with the early stages of viral DNA synthesis. Its derivatives also show good medicinal effects, such as monophosphate which has the effect of inhibiting the replication of the hepatitis B virus. We mainly use biosynthetic and chemical methods to produce 9-β-D-arabinofuranosyladenine.

• The chemical method has many advantages, such as a short reaction cycle, high production efficiency, wide source of synthetic raw materials, and low price.
• The biosynthetic method has the advantages of mild reaction conditions, high specificity, high conversion rate, and easy separation of products.

We optimize based on the original production route. We offer 9-β-D-arabinofuranosyladenine in small sizes. We will also modify 9-β-D-arabinofuranosyladenine to produce new compounds.

Applications

• The optimized method enables the production of high-quality cytarabine. It is used to study and construct self-assembled nano-delivery systems of cytarabine precursors.
• Adenosine produced by the optimized method is used to study its side effects on development and growth.
• Modified production of nucleosides plays a vital role in the research of the effects of adenosine in the synergistic treatment of diseases with other drugs.

Advantages

• We have optimized the production and assay process of various products such as cytarabine. The product reaction cycle is short and the production efficiency is high.
• Our optimized cytarabine production route overcomes the disadvantages of expensive raw material costs, low yield, high reagent toxicity, etc.
• The optimized 9-β-D-arabinofuranosyladenine production method has the advantages of mild reaction conditions, high conversion rate, easy separation, high specificity, etc., of the product.

CD BioGlyco excels in the production of nucleoside analogs through its chemical synthesis and biosynthesis expertise. Feel free to contact us with your requirements.