Characteristics of the Microbial Synthesis Method

Microorganisms are tiny organisms that are widely found in nature and are too small and numerous to be seen directly by the naked eye. Microorganisms can be categorized into prokaryotic, eukaryotic, and non-cellular microorganisms according to their evolutionary level and traits. The number of microorganisms in nature is roughly estimated to be in the order of millions, making them a rich and diverse resource on the earth. Nowadays, microbial technology is an integral part of bioengineering. Microbial technology has been successfully applied in various industries such as medicine, food, and textile. With the further development of biotechnology, it has become easier to build non-natural biomanufacturing systems based on microorganisms. For example, microorganisms can be used to efficiently produce protein macromolecules, DNA/RNA strands, and nucleotides.

Fig.1 Different forms of microorganisms. (Wikipedia)

Nucleotide Microbial Synthesis Service at CD BioGlyco

Nucleotides are an indispensable class of substances for human beings, and the microbial synthesis method has the advantages of mild conditions, high specificity, high production efficiency, simple operation, and low toxicity. Therefore, at CD BioGlyco, we will utilize the action of microorganisms themselves to produce nucleotides.

Principle of nucleotide synthesis by microbial method: utilizing the fermentation action of microorganisms.

To produce nucleotides more efficiently, we will optimize the metabolic pathways and regulatory mechanisms of microorganisms, and also improve the permeability of cell membranes for nucleotides.

In addition to the production of nucleotides by direct microbial fermentation, we offer the following production pathways:

• Microbial fermentation followed by chemical synthesis (phosphorylation reaction)
• The first step is microbial fermentation and the second step utilizes enzymatic conversion

During the production of nucleotides by microorganisms, we continuously optimize the reaction process and provide multiple production paths for clients to choose from.

Fig.2 Three methods of microbial synthesis. (CD BioGlyco)

Applications

• In food processing, nucleotides are used in the development of food additives for infants and children.
• Nucleotides are used in the development of intermediates for targeted therapeutic drugs.
• Nucleotides are used in the research of drugs for the treatment of AIDS.

Advantages

• Microbial synthesis of nucleotides is done under mild conditions and low toxicity and hence this helps in the application of nucleotides in drug production.
• Synthesis of nucleotides helps to explore the structure and function of nucleotides in depth.
• We have Custom Production Research Solutions that help our clients to conduct research with high quality.

CD BioGlyco has a first-class laboratory with biosynthesis technology in line with international high-level technology. We have been researching in the direction of producing nucleotides for many years and our technology has become more mature. We provide custom production to each of our clients. If you are interested in our services, please feel free to contact us.