Properties
Description
NVP-TNKS656, soluble in DMSO and warmed ethanol and insoluble in water, binds to the PARP enzyme's active site, preventing it from repairing single-strand DNA breaks.
Molecular Formula
C27H34N4O5
Solubility
DMSO: 89 mg/mL (179.95 mM); Water: Insoluble; Warmed ethanol: 9 mg/mL (18.19 mM)
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
NVP-TNKS656 can be used to inhibit tankyrase, providing insights into the regulation of Wnt signaling.