PARP inhibitor NVP-TNKS656, Purity ≥98%

Synonym: 1419949-20-4; NVP-TNKS656; TNKS656; TNKS-656; N-(Cyclopropylmethyl)-2-(4-(4-methoxybenzoyl)piperidin-1-yl)-N-((4-oxo-3,5,7,8-tetrahydro-4H-pyrano[4,3-d]pyrimidin-2-yl)methyl)acetamide; PARP inhibitor

CAS Number: 1419949-20-4
Compound CID: 136237316

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

NVP-TNKS656, soluble in DMSO and warmed ethanol and insoluble in water, binds to the PARP enzyme's active site, preventing it from repairing single-strand DNA breaks.

Molecular Weight

494.58

Molecular Formula

C₂₇H₃₄N₄O₅

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 89 mg/mL (179.95 mM); Water: Insoluble; Warmed ethanol: 9 mg/mL (18.19 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

NVP-TNKS656 can be used to inhibit tankyrase, providing insights into the regulation of Wnt signaling.