Postsynthetic Glycan Modification Inhibitor Development Service

Postsynthetic Glycan Modification Inhibitor Development Services at CD BioGlyco

Abnormalities in postsynthesis glycan modification cause the development of diseases. Therefore, the development of inhibitors of postsynthesis glycan modifications has important implications for the regulation of physiological activities. At CD BioGlyco, we provide postsynthetic modification inhibitor development services.

The post-synthesis glycan modification process is dominated by specific transferase enzymes, which we target to develop post-synthesis glycan modification inhibitors.

• High-throughput screening
  We offer luciferase assays, fluorescent probes, and fluorescent labeling assays to preliminarily screen subject scaffold structures for inhibitory effects and analyze their inhibitory capacity in cells.
• Kinetic analysis
  We use kinetic experiments in biology to provide kinetic analyses to compare the ability of compound molecules with different structures to inhibit post-synthesis glycan modifications and to explore their mechanisms of inhibition.
• Optimization and validation
  We optimize and validate the compounds obtained from screening in well plates. The half inhibitory concentration values and inhibitory effects of different inhibitors are compared to optimize the inhibitor with optimal inhibitory effect.
• Inhibition assessment
  We provide cell and animal models to assess the inhibitory effect and safety of the developed inhibitor molecules using techniques such as Western blotting and flow cytometry.

The specific post-synthesis glycan modification inhibitor services we offer are listed below:

Fig.1 Postsynthetic glycan modification inhibitor development services. (CD BioGlyco)

Applications of Postsynthetic Glycan Modification Inhibitors

• Postsynthetic glycan modification inhibitors can be used in the research of physiological activities such as cell-to-cell, cell-to-glycan, and glycan-to-host signaling.
• Postsynthetic glycan modification inhibitors can be used to probe glycosylation sites, glycosylation pathways, physiological activities of production, and so on.
• Postsynthetic glycan modification inhibitors can be used in research on the treatment of certain tumors or viruses.

Advantages of Us

• We offer postsynthetic glycan modification inhibitor development services covering a wide range of types.
• We design and develop postsynthetic glycan modification inhibitors with high specificity and stability.
• We have a first-class technology and a professional inhibitor development team.

CD BioGlyco provides systematic Glycosylation Inhibitor Development Services. Each of our experimental protocols is developed by experts with many years of experience in the field. Our broad vision provides professional and high-quality assistance to our clients' research projects. We also hope to be your right-hand man in the field of glycobiology. If you are interested in our services, please feel free to contact us.