Properties
Description
Rolapitant inhibits the signaling pathway between G-protein-coupled receptors (GPCRs) and G proteins. It targets gerbil NK1, guinea pig NK1, human NK1, monkey NK1, mouse NK1, rabbit NK1, and rat NK1.
Molecular Formula
C25H26F6N2O2
Targets
Gerbil NK1: 0.13 nM; Guinea pig NK1: 0.72 nM; Human NK1: 0.66 nM; Monkey NK1: 2.5 nM; Mouse NK1: 60.4 nM; Rabbit NK1: 31.7 nM; Rat NK1: 78.6 nM
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
Rolapitant can be studied for its effect on blocking the NK-1 receptor can help control nausea and vomiting in this setting as well.
Storage
Store at -20°C, and keep desiccated.
