VEGFR inhibitor Vatalanib 2HCl, Purity ≥98%

Synonym: 212141-51-0; VEGFR inhibitor; Vatalanib; PTK787; PTK/ZK

CAS Number: 212141-51-0
Compound CID: 22386467

Product Size

10 mg; 50 mg; 100 mg; 200 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Vatalanib 2HCl, soluble in DMSO, water and ethanol, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against VEGFR. It targets VEGFR1/FLT1, VEGFR2/Flk1, c-Fms, c-Kit, PDGFRβ, VEGFR2/KDR, and VEGFR3/FLT4.

Molecular Weight

419.7

Molecular Formula

C₂₀H₁₇Cl₃N₄

Targets

VEGFR1/FLT1: 77 nM; VEGFR2/Flk1: 270 nM; c-Fms: 1.4 μM; c-Kit: 730 nM; PDGFRβ: 580 nM; VEGFR2/KDR: 37 nM; VEGFR3/FLT4: 660 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 77 mg/mL (183.45 mM); Water: 9 mg/mL (21.44 mM); Ethanol: 5 mg/mL (11.91 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

Vatalanib 2HCl is employed in research to block VEGFR, crucial for understanding its role in tumor angiogenesis and growth.