Aspergillus fumigatus Antigen Production Service

Application Value of Aspergillus fumigatus Antigen

The cell wall of A. fumigatus is a complex structure including different antigens such as glucan and galactomannan, which are recognized via the immune system and trigger a corresponding immune response. When A. fumigatus conidia are inhaled into the body, healthy bodies efficiently clear conidia from the mucociliary tract, whereas immunocompromised patients fail to do it, resulting in invasive aspergillosis (IA). The formation of Aspergillus cell wall will promote host cell adhesion and induce endocytosis, followed by proteases released by Aspergillus hyphae to remotely invade parenchyma tissues and blood vessels, thus aggravating the severity of IA. By studying and applying A. fumigatus antigens, we understand the immunological characteristics of A. fumigatus infection and provide support for the diagnosis, treatment, and prevention of related diseases.

Fig.1 The pathogenesis of IA. (Lian, et al., 2021)

A. fumigatus Antigen Production Services at CD BioGlyco

• Antigen production services

CD BioGlyco provides large-scale A. fumigatus antigen production services. By optimizing culture conditions and production strategies, we use different culture methods to efficiently produce large amounts of antigens, such as solid culture or liquid culture.

• Antigen extraction and purification services

CD BioGlyco uses appropriate methods and technologies to extract and purify target antigens generated by A. fumigatus to obtain high-purity and high-activity antigens, including cell disruption, ultrafiltration, gel filtration, centrifugation, column chromatography, and other steps.

• Antigen quantification services

CD BioGlyco determines the concentration of A. fumigatus antigen using appropriate quantitative methods such as colorimetry, spectrometry, or ELISA. Standardizing antigens ensures consistency and comparability between batches.

• Antigen characterization services

CD BioGlyco evaluates the molecular identity, structural characteristics, and purity characteristics of A. fumigatus antigens through a variety of analytical methods, such as SDS-PAGE, western blot, and mass spectrometry.

• Vaccine development services

CD BioGlyco has the innovative Glyco™ Vaccine Development Platform, we provide high-quality A. fumigatus antigen-based vaccine development services.

• Customized services

In addition, CD BioGlyco provides custom A. fumigatus antigen production services based on client needs. We individually design and produce for specific antigen types, purity requirements, and batch requirements.

Fig.2 A. fumigatusantigen production services. (CD BioGlyco)

Applications

• Clinical testing tool: A. fumigatus is a common fungal pathogen that may induce respiratory infections and allergic reactions. Clinical laboratories are provided with detection tools to help diagnose and monitor A. fumigatus infections by producing A. fumigatus antigens.
• Vaccine research: A. fumigatus antigens are applied in vaccine development, especially for people who are highly susceptible to the fungus, such as those with compromised immune systems. The production of A. fumigatus antigen is one of the key steps in vaccine research and development.
• Drug screening: By producing A. fumigatus antigens, the antifungal activity and immunomodulatory effects of compounds on A. fumigatus are evaluated, thereby providing tools for drug screening and evaluation.

Advantages

• CD BioGlyco has mature antigen production experience and efficiently produces high-purity and high-quality A. fumigatus antigens.
• CD BioGlyco provides custom A. fumigatus antigen production services based on the client's specific needs, including specific specifications, purity requirements, or other custom needs.
• CD BioGlyco has established a strict quality control process to ensure the quality and stability of A. fumigatus antigen. Antigens are evaluated through appropriate analytical methods and detection methods to ensure their purity, activity, and consistency.

CD BioGlyco has reliable A. fumigatus antigen production capabilities and meets project requirements of different scales and complexities on demand, we also provide clients with comprehensive technical support and professional guidance. Please feel free to contact us in time if you are interested in learning about our antigen production services.

References

1. Lian, X.; et al. Monoclonal antibodies and invasive aspergillosis: diagnostic and therapeutic perspectives. International Journal of Molecular Sciences. 2021, 23(10): 5563.
2. Sales-Campos, H.; et al. The immune interplay between the host and the pathogen in Aspergillus fumigatus lung infection. BioMed Research International. 2013, 2013.