Base-based Modification Service

Commonly Used Methods for Base Modification

Base-based modification of nucleosides and nucleotides can be achieved by introducing different chemical groups into the molecular structure of the nucleoside or nucleotide by utilizing organic synthesis. For example, different functional groups are introduced at specific positions by chemical reactions such as esterification, substitution, and oxidation reactions. Another approach is by introducing a specific chemical functional group on a starting molecule and then converting it to the target modifying group using a chemical reaction. For example, by introducing an acetone or allylacetone functional group, it can be converted to an amino group or a hydroxyl group after a selective chemical reaction. By modification, the properties such as solubility, stability, and affinity can be changed, thus improving the efficacy and bioavailability of drugs. In addition, modified nucleosides and nucleotides can be used for labeling molecules, probe design, and biosensors, providing a powerful tool and platform for scientific research.

Fig.1 Modification of protected pseudouridine. (Hocek, 2009)

Base-based Modification Service at CD BioGlyco

CD BioGlyco is a leading company providing specialized nucleoside & nucleotide Modification services. With innovation and excellence in mind, we are committed to providing high-quality, customized modification solutions to our clients. Our modification services include halogenation, N-conjugation, and azotation.

Applications

• Modifications to nucleotides help researchers gain insight into the structure and function of DNA and RNA.
• Nucleotide modification is an essential medicinal chemistry tool that can significantly enhance the stability and selectivity of drugs by altering the structure of nucleotide molecules.
• Nucleotide modifications can improve efficacy and reduce side effects, for example, by altering the steric configuration of a drug molecule and increasing its match to the receptor structure, thereby enhancing the affinity of the drug.

Advantages of Us

• With a focus on compliance and innovation, we are committed to providing our clients with a more satisfying service experience through innovation and technological advancements.
• Our experts have extensive experience and expertise in the fields of organic chemical synthesis, multi-step synthesis, and catalytic reactions.
• We have invested significant resources and R&D efforts in synthetic technologies.

CD BioGlyco provides base-based nucleoside & nucleotide modification services based on our leading platform and expertise. Our efficient workflow and strict quality management system ensure the on-time delivery of projects and help our clients achieve success in drug discovery, bioscience research, and other fields. If you need base-based services, please feel free to contact us for more detailed information.