Nucleoside & Nucleotide Modification Service

Biological Significance of Modification of Nucleoside & Nucleotide

Modification of nucleosides and nucleotides is pivotal in the functional regulation of cells and life activities. The function of DNA and RNA can be modulated by changing their structure and introducing different chemical groups. Such modifications are essential to the process of drug discovery and development. For example, by targeting specific nucleotide modifications, researchers can design drugs with specific biological activities to inhibit the growth of pathogens or treat certain genetic diseases. Modifications such as glycosylation, phosphorylation, and acetylation can change nucleotide molecule charge state and structure thus impacting signaling pathways The techniques of nucleotide modification can also be used for gene editing. By modifying nucleotide molecules, researchers can design and develop nucleic acid sequences with specific functions for editing or repairing a patient's genes, which is important for several inherited diseases.

Fig.1 The arrangement of nucleotides within the structure of nucleic acids. (Wikipedia)

Nucleoside & Nucleotide Modification Service at CD BioGlyco

CD BioGlyco has a comprehensive and state-of-the-art Glyco™ Synthesis Platform that integrates the latest synthetic methods, processes, and equipment to provide you with efficient and reliable modification services. Some of the Nucleoside & Nucleotide modifications we provide are as follows:

Applications

• By chemically modifying nucleotides, drugs with specific biological activities can be designed and developed.
• Modified nucleotides can be used in drug discovery, including the development of drugs, vaccines, and antibodies that target specific genes or proteins.
• Modified nucleotides can be used to construct biosensors for the detection of various biomolecules, chemicals, or pollutants in the environment.

Advantages of Us

• We offer many different modification methods to provide our clients with more possibilities for their research.
• Our highly flexible synthetic strategies allow us to design optimal synthetic pathways for complex chemical structures and ensure high yields and purity of the synthesized products
• We utilize state-of-the-art technical equipment and stringent quality management processes to ensure that our services operate at a high standard.

CD BioGlyco adopts a variety of advanced chemical and chemoenzymatic synthesis techniques to provide custom Nucleoside & Nucleotide modification services for clients around the world. If you need Nucleoside & Nucleotide modification services, please feel free to contact us for more detailed information.