Saccharides, compounds formed by covalent bonding of saccharides, biomolecules (such as proteins, peptides, lipids, nucleic acids, and antibodies), and other small molecules are ubiquitous. They are located on the cell surface and inside the cell and play a key role in processes such as cell interaction development of vaccines against cancer, viral and bacterial infections, and many other diseases. The conjugation of sugar and other substances also improves the original properties of these substances, such as stability and solubility.
Proteins and nucleic acids can be obtained in a homogeneous form through recombinant expression and polymerase chain reaction, respectively. Unlike them, the biosynthesis of sugars and glycoconjugates does not have a fixed template and uniform model. Therefore, sugar-related substances isolated from biological samples usually exist in the form of heterogeneous mixtures of different glycan structures. To solve this problem, CD BioGlyco has developed different strategies for obtaining homogenous sugar-related substances, including chemical, enzymatic, and chemoenzymatic methods, and can also provide different modifications according to customer needs. Our service helps study the structure and function of sugars and glycoconjugates and the development of new biological drugs for major diseases.
Fig.1 Comparison of natural glycoconjugates and synthetic glycoconjugates. (Zhang, 2018)
CD BioGlyco has many years of experience in the field of custom synthesis. We have a professional technical team to provide guidance for customers' projects, and tailor synthesis schemes according to needs. We hope to start the exploration of glycobiology with you. If you are interested in our services, please contact us for more detailed information.
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