Applications of Deoxyadenosine Derivative

With the deepening of Deoxyadenosine research, it has been found that the modification of different sites on the skeleton of deoxyadenosine. can present various pharmaceutical activities. For example, the modification of the substrate at the 2-position produces the activity of anti-hairy cell leukemia. The modification of the substrate at the 6-position can treat Kawasaki disease. The production of deoxyadenosine derivatives and the modification of deoxyadenosine derivatives have also become hot research for obtaining new drug molecules.

Modified deoxyadenosine can act directly on the body and participate in the production of proteins and nucleic acids. It has a high degree of efficiency and immediacy not found in many synthetic macromolecular drugs. Compared with other compounds, deoxyadenosine derivatives have significant antiviral activity. Meanwhile, deoxyadenosine and its derivatives can also be used in agriculture. Some of the deoxyadenosine derivatives have been found to have anticancer properties.

Nucleoside-based Deoxyadenosine Derivative Production Service at CD BioGlyco

CD BioGlyco is committed to providing reliable and efficient means of producing deoxyadenosine derivatives. We produce deoxyadenosine derivatives mainly by chemical method. We aim to help our clients solve the problems and challenges encountered in deoxyadenosine derivatives together.

• Deoxyadenosine derivative production service

The research of deoxyadenosine modification and derivative production is mainly divided into two aspects: base-based modification research and sugar-based modification research. The former modification mainly focuses on the purine ring 1-position, 2-position, 6-position, and 8-position. The latter modification focuses on the opening and closing of the deoxyribose ring and the replacement of functional groups. Taken together, deoxyadenosine mainly focuses on the 6-position, 8-position, and deoxyribose. The modification of each site will have a significant therapeutic effect on a particular disease. For this reason, we have a dedicated research team to produce deoxyadenosine derivatives. We aim to provide a convenient production method for the development of deoxyadenosine derivatives for drug discovery.

The traditional method of deoxyadenosine 6-site modification cannot be separated from palladium catalysis. However, this method has the disadvantages of low yield, high contamination, slow reaction speed, cumbersome steps, and expensive reagents. Through continuous improvement, based on the Buchwald-Hartwig reaction, we used cuprous salt-catalyzed production of deoxyadenosine 6-position aryl amination derivatives. This method is high-yield, low pollution, and inexpensive. Based on the production method of Buchwald-Hartwig coupling, our synthetic pathway consists of two kinds:

• For 2'-deoxyadenosine (2'-dAdo) 6-position and 8-position modification, we obtain a route with high yield, low pollution, and inexpensive reagents to obtain a series of deoxyadenosine base-modified derivatives.
• For the phosphorylation modification of the 5' position of deoxyribose, a simpler triphosphorylation reaction method is obtained. An experimental route with higher purity and yield is obtained.

According to the client's needs, we will formulate the corresponding production method and complete the production, structure analysis, etc.

Fig.1 Production process of deoxyadenosine derivatives. (CD BioGlyco)

• Deoxyadenosine derivative products

We offer deoxyadenosine derivative products with different specifications for research purposes. Our product range includes sodium ((2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxytetrahydrofuran-2-yl)methyl hydrogendiphosphate, 2'-Deoxyadenosine-5'-monophosphate, 2-CdA, 2'-Deoxyadenosine-5'-triphosphate (dATP), Disodium Salt, 2'-Deoxyadenosine 5'-monophosphate disodium, etc.

Applications of Nucleoside-based Deoxyadenosine Derivative Production Service

• The production of deoxyadenosine derivatives with different structures is used in the development of new drugs, such as anti-cancer drugs, anti-AIDS drugs, etc.
• Deoxyadenosine derivatives with different structures are used in agriculture for the development of herbicides.
• The production of novel deoxyadenosine derivatives can lay the foundation for the research of DNA and RNA oxidative damage detection methods.

Advantages

• We have improved the production route of deoxyadenosine derivative to avoid the disadvantages of low yield, high pollution, slow reaction speed, and so on.
• We are equipped with internationally advanced instruments and equipment to provide an integrated solution for deoxyadenosine derivatives.
• We will carry out relevant testing services, including purity and structure analysis, to ensure the consistency and effectiveness of the product.

CD BioGlyco is experienced in the production of deoxyadenosine derivatives. We are committed to providing our clients with high-quality products and low-priced, efficient production services. Besides, we also provide Nucleoside-based Deoxycytidine Derivative Production Service and Nucleoside-based Deoxyguanosine Derivative Production Service. If you want to inquire about the production process and price of deoxyadenosine derivative, please feel free to contact us.