Applications of Deoxyguanosine Derivative in Medicine

With the deepening of Deoxyguanosine derivative research, its application in medicine has been gradually developed. A number of deoxyguanosine derivative drugs have been produced for use as reverse transcriptase inhibitors. They are mainly phosphorylated intracellularly to form an active metabolite of 5'-triphosphate, which competes with nucleoside 5'-triphosphate. They inhibit HIV replication by triggering premature termination of the viral RNA strand. Their affinity for HIV-1 RT is much stronger than that for normal intracellular DNA polymerase, so they have a certain therapeutic index. In addition to this, a deoxyguanosine derivative, 8-hydroxy-2 deoxyguanosine (8-OHdG), has been discovered. 8-OHdG is a product of oxidative DNA damage caused by reactive oxygen species (ROS). It is often used as a marker in experiments to detect oxidative damage and DNA mutations. 8-OHdG has been widely used in experiments and clinics. It is involved in the detection of oxidative stress and lesions and the analysis of the mechanism.

Fig.1 Structure of 8-OHdG. (Wikipedia)

Nucleoside-based Deoxyguanosine Derivative Production Service at CD BioGlyco

CD BioGlyco is experienced in nucleoside derivative production. We aim to provide our clients with deoxyguanosine derivative production services with high yield, few steps, and low cost.

• Deoxyguanosine derivative production service

We mainly produce deoxyguanosine derivatives by Chemical Method. By the solid-phosphoramidite chemical method, deoxyguanosine derivatives with special modifications are produced. We introduce certain substituent groups at the C-8 position of the purine ring in the form of carbon-carbon, carbon-oxygen, carbon-sulfur, carbon-nitrogen bonds, etc. The produced derivatives may have important biomedical activities such as antiviral, anticancer, blood pressure lowering, etc. The C-8-modified purine compounds are modified with fluorescent groups to act as pH-detecting fluorescent probes. We also incorporate a fluorescent group at the C-8 position.

In order to further explore effective, selective, and sensitive therapeutic agents for tumors and viral infections without toxic side effects, a lot of research has been carried out in this field in recent years. Dideoxyguanosinic acid is a typical representative of them. It has the advantages of chemical stability, obvious enzyme properties, and potential antiviral activity. Upon request, we provide production services for dideoxyguanosinic acid and its derivatives. We also test its inhibitory effect on DNA and RNA polymerase stability, etc. Besides, we are also responsible for the testing of anti-cancer and anti-virus activities.

• Deoxyguanosine derivative products

We supply deoxyguanosine derivative products in small sizes. Our products include the following.

Fig.2 Deoxyguanosine derivatives produced. (CD BioGlyco)

Applications of Nucleoside-based Deoxyguanosine Derivative Production Service

• Modification of different parts of deoxyguanosine can be used to develop fluorescent probes for pH detection.
• Oxidative DNA damage may lead to diseases in organisms. Deoxyguanosine derivative can be used in studies of indicators of oxidative stress and disease.
• The deoxyguanosine derivative with different structures is important in research of genetic diagnosis, detection of pathogenic microorganisms, and early tumor screening.

Advantages

• The way we produce deoxyguanosine derivatives can minimize the generation of by-products. We guarantee to provide high-quality, efficient, and green products.
• A high-standard quality system is adopted to strictly manage key raw materials and auxiliaries, process, transfer and validation, and drug production.
• We conduct real-time testing during the production process to ensure the structure and purity of the product.

CD BioGlyco is committed to providing more convenient services to our partners who are developing antitumor, antiviral, and other drugs. After clarifying your product requirements, we will equip our professional team to design a deoxyguanosine derivative production program. In addition, we also provide Deoxythymidine Derivative Production Services, etc. Welcome to contact us for more information.