Applications of Deoxycytidine Derivative in Disease Management

Structural modification and transformation of nucleoside analogs to seek drugs with high efficiency, low toxicity, and high selectivity is currently a hotspot in the research of the majority of drug workers. Studies have shown that the Deoxycytidine derivative has anti-tumor and anti-virus activities. In anti-tumor, it exerts its anti-tumor activity by binding with DNA strands, inhibiting DNA synthesis and leading to cell death. Some antiviral and tumor drugs have been produced. For example, 2',2'-difluoro-2'-deoxycytidine. It has some anti-tumor activity and is used to treat a variety of solid tumors. In antiviral, deoxycytidine derivative inhibits reverse transcriptase activity and disrupts viral transcription, thereby preventing viral invasion of target cells and exerting antiviral activity, such as 2'-3'-dideoxycytidine (DDC).

Fig.1 The structure of DDC. (Wikipedia)

Nucleoside-based Deoxycytidine Derivative Production Service at CD BioGlyco

CD BioGlyco continues to simplify the production of deoxycytidine derivatives and reduce the cost of auxiliary materials. In order to determine the optimal production solution, different production methods need to be compared. We choose the production routes with mild reaction conditions, high specificity, mild conditions of action, and simple handling.

Fig.2 The production process of deoxycytidine derivatives. (CD BioGlyco)

• Deoxycytidine derivative production service

We produce deoxycytidine derivative by Chemical Method. During the production process, we study the effect of reactant structure, reaction solvent, alkaline reagent, and reaction temperature on the production process of the derivative. We have various equipment such as Fourier transform infrared spectrometer, nuclear magnetic resonance spectroscopy, etc. After production, we analyze the structure of the compounds by infrared spectroscopy (IR), mass spectrometry (MS), nuclear magnetic resonance hydrogen spectroscopy (¹H NMR), and nuclear magnetic resonance carbon spectroscopy (¹³C NMR).

Some deoxycytidine derivative drugs have been developed for the research of HIV infection treatment and cancer treatment. However, these drugs have serious side effects during treatment and drug-resistant strains may emerge. Modification of deoxycytidine derivative is a new direction to find low and efficient drugs. We provide novel deoxycytidine derivative development services. We utilize the collocation principle of drug design to combine deoxycytidine derivatives with other compounds to generate novel derivatives. We will design the production program according to the client's requirements. We will also be responsible for the subsequent testing of the produced products for antiviral and antitumor activities if required by the client.

• Deoxycytidine derivative products

We offer deoxycytidine derivative products with different specifications. Our products include but are not limited to the following.

• 5-Acetoxymethyl-2'-deoxycytidine (5-AO-dC)

It is a deoxycytidine derivative that inhibits viral replication. Studies have shown that it has some anti-tumor activity and can be effective in treating cancer cells.

• dFdCyd

It is used for the research of the treatment of advanced cancers such as lung and breast cancer. It kills tumor cells by interfering with the cell replication process.

• DDC

It is a reverse transcriptase inhibitor. As an antiviral deoxycytidine derivative, it inhibits HIV replication. It is used for research into the treatment of AIDS and AIDS-related syndromes.

• 5-Aza-2'-deoxycytidine (DAC)

It is a deoxycytidine derivative that inhibits the activity of DNA methyltransferase, thereby demethylating DNA and affecting cell growth, differentiation, etc. It has antitumor activity.

Applications of Nucleoside-based Deoxycytidine Derivative Production Service

• Deoxycytidine derivatives can be used as DNA methyltransferase inhibitors. Their production is used for the research of DNA methyltransferase inhibitors to regulate gene expression.
• The technique of production of deoxycytidine derivatives can be used to develop low-toxicity, high-efficiency drugs such as antivirals.
• Deoxycytidine derivatives can be used to study their effects on the proliferation, migration, etc. of drug-resistant cancer cell lines.

Advantages

• Our researchers are highly experienced. Optimized reactions minimize the formation of by-products.
• Nucleoside derivatives are involved in various important processes of biological activities. They are also widely used in biology, medicine, and other fields. Our experimental platform is well-equipped. Compounds of different structures can be produced.
• During the completion of the project, our senior research team will dock the whole process to provide smoother and professional technical services.

CD BioGlyco widely serves basic life science research, drug development, and basic medical research. We have a professional deoxycytidine derivative production and analysis team. Besides, we also provide Nucleoside-based Deoxyadenosine Derivative Production Service. Welcome to contact us for more information. We will return your trust to us with high-quality and efficient service.