Oligonucleotides attached to different chemical groups have become important tools in medicinal chemistry, molecular biology, disease diagnosis, and other fields. After the introduction of modification groups, the properties and functions of the oligonucleotides will be changed and their application scope will be expanded such as changes in the penetration of DNA fragments to cell membranes, changes in resistance to nucleases, and changes in thermal stability. If the chemically active groups are combined into oligonucleotides, conjugants combined with peptides, dyes, and other molecules can be obtained. As a therapeutic approach, oligonucleotide modification can improve the pharmacokinetic and pharmacodynamic properties, and increase the efficiency of oligonucleotide delivery and penetration. Oligonucleotides have powerful functions as primers or probes in the laboratory, and synthesizing modified oligonucleotides with special chemical groups is a key step for the success of the experiment.
Fig.1 Cholesterol-modified oligonucleotide and its application in DNA-encoded chemical library synthesis. (Yang, et al., 2021)
CD BioGlyco develops different synthesis and modification technologies and provides end-to-end services to help clients select suitable modification solutions to support their research in various biotechnologies.
CD BioGlyco has expertise in Oligonucleotide Synthesis and Oligonucleotide Modification. we have a strict quality assurance system to ensure product quality and timely delivery. If you are interested in our Custom Sugar-nucleotides Synthesis service, please feel free to contact us immediately for more information.
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