Characteristics of Guanosine

Guanosine, with the molecular formula C₁₀H₁₃N₅O₅, is a type of nucleoside and is composed of guanine and a ribose (furanose) ring, which are connected by a β-N9-ligand sugar bond. Guanosine can be phosphorylated to guanosine monophosphate (GMP), cyclic guanosine monophosphate (cGMP), guanosine diphosphate (GDP), or guanosine triphosphate (GTP). Guanosine is widely used as an important intermediate for food and pharmaceutical products. It can be used for the synthesis of food freshness enhancer 5'-guanylic acid disodium salt, flavor-presenting nucleotide disodium salt, and nucleoside antiviral drugs. It is also the main raw material used in the manufacture of acyclic guanosine (Acyclovir), triazole nucleoside (ATC), guanosine triphosphate sodium (GTP), and other drugs. In addition, guanosine also has a very important role in the chemical field.

Fig.1 Chemical structure of guanosine and products of its phosphorylation. (CD BioGlyco)

Nucleoside-based Guanosine Production Service at CD BioGlyco

Guanosine is so valuable in the food, pharmaceutical, and chemical industries that a comprehensive study of its production services is necessary. At CD BioGlyco, we offer several strategies for the production of guanosine.

• RNA hydrolysis
  RNA is connected by phosphodiester bonds, so after hydrolysis, phosphodiester bond breakage will get nucleotides. And the nucleotide's further decomposition can get the target nucleoside.
• Chemical Synthesis
  We choose a specific catalyst to catalyze the conversion of nucleotides into more structurally stable nucleosides to prepare guanosine.
• Microbial fermentation
  Fermentation by microorganisms is also an excellent method for mass production of guanosine. At CD BioGlyco, we modify the strains and screen the active enzymes to improve the metabolic activity of the microorganisms. Finally, pure guanosine is produced in the strain. This method is efficient and environmentally friendly, does not contain any toxic substances, and enables the production of guanosine in large quantities for our customers.

In addition to the production of guanosine, we also offer testing services to assay guanosine. At CD BioGlyco, we offer ion exchange, enzymatic, paper electrophoresis, paper chromatography, thin layer chromatography, and high-performance liquid chromatography for qualitative and quantitative analysis of guanosine.

Fig.2 Methods of production and testing of guanosine. (CD BioGlyco)

Applications

• Guanosine is used in the development of pharmaceutical intermediates.
• Guanosine is used in the development of food flavorings in the food processing industry.
• Guanosine could be used in the research of fluorescent probe reagents.

Advantages

• The production of guanine nucleosides contributes to the in-depth exploration of their biological functions.
• The production of guanine nucleosides helps to study the structure of nucleosides.

CD BioGlyco has many years of experience in the field of custom synthesis of nucleosides. We have a dedicated technical team to guide our clients in their research projects and custom production solutions on demand. If you are interested in our services, please feel free to contact us for more details.